rhBMP_2复合制剂用于犬牙根尖诱导成形术的实验研究.pdfVIP

2010 18 4 Beijing Jo rnal of Stomatology A g st 2010, Vol 18, No4 209 rhBMP-2 蒋月桂 苟建重 王宝彦 宋健玲 孙斌 孙沫逸 -2( rhBMP-2/Co/HA ) , , rhBM P-2/C o/HA , 12 X 2 , , 100% ; 45 , , 9375% ; (P 005), rhBM P-2/Co /HA rhBMP-2; ; ; ; ; R78134 A 1006-673X( 2010) 04-0209-03 An experim ental study of root-end induction of rhBM P-2/Co/HA com pounds in dogs JIANG Yue-g ui, GO U J ian- zhong, WAN G B ao-y an, SONG J ian-lin, S UN B in, S UN M o-y iD ep artm ent o E ndodon tics, S tom atolog ical H osp ital, X ian J iao tong Univ ersity, X ian 710004, Ch ina Abstract Objecti e To eval ate the effect of rhBMP-2/Co/HA on the root form ation in mi m at re teeth of dogsM ethods Them odel of perirad ic lar lesions in dogs root were established, and then the canals w ere debrided and filledw ith rhBM P-2/Co /HA in the expermi ental gro p and w ith calci m hydrox ide in the control gro pThe dogs w ere e thanatized after 12w eeksThe hard tiss e form ation was eval ated by X-ray and histologyR esults The rhBMP-2/Co/ HA gro p and the control had d ifferen t ap ical clos re rate in X-ray, b t the difference w as not sign ificant (P 005 ). H istological exam ination showed ap ical clos re w ith a calcific barrier in both gro psConclusion rhBMP-2/Co/HA compo nds has good b iocom patib ility and b iological activity in apexification Key words rhBMP-2; Type collagen; Hydroxyapatite; Dog; Apexification; Calci m hydrox ide , , 1 , , ( ); -2 , , ( recomb inant h man bone morphogenetic protein-2, rhBMP-2 rhBMP-2) ( ,