GnRH_蛋白在子宫内膜异位症患者中的表达及意义.pdf

30 1 http: / /www. gjbl. net ol. 30 N o. 1 2010 1 International Journal ofPathology and C linicalM edicine Jan. 2010 GnRH 邹颖, 黄凤英 (中南大学湘雅二医院妇产科, 长沙 410011) [] : 检测 GnRH蛋白在子宫内膜异位症患者异位子宫内膜在位子宫内膜和正常子宫内膜中的 表达情况, 同时分 其表达是否与子宫内膜月经周期有关: 采用免疫组织化学 SP法检测 GnRH蛋白在异 位内膜在位内膜及正常子宫内膜组织中的表达情况, 并分 和比较其表达是否有差异: GnRH蛋白在子 宫内膜异位症患者异位在位子宫内膜及正常子宫内膜中均有表达, 阳性表达定位于子宫内膜腺体及间质细胞的 细胞质; GnRH蛋白在异位内膜在位内膜及对照组正常内膜的表达依次增强, 两两比较差异有统计学意义(P 0. 05); GnRH蛋白在正常子宫内膜分泌期表达强于增生期(P 0. 05) , 且以分泌早中期最强, 显著强于增生期和 分泌晚期(P 0. 01), 而异位组或在位组的分泌期与增生期比较, 差异无统计学意义 (P 0. 05): GnRH蛋 白在子宫内膜异位症的发病中以及在人类月经生理方面可能起重要作用 [] 子宫内膜异位症; GnRH蛋白; 子宫内膜; 免疫组织化学 do:i 10. 3969/.j issn. 2010. 01. 005 Expression ofGnRH protein in patientswith endometriosis and its significance ZOU Ying, HUANG Fengying (D ep artm en t of Gyn ecology and Obste trics, S econd X iangya H osp ital, C en tral S ou th University, Chang sha 410011, Ch ina [Abstract] Objective To exam ine expression ofGnRH protein in patientsw ithandw ithout endometriosis and to determ ine its relation to them enstrual cycle. Methods The expression ofGnRH protein was detected in the norma,l ectopic, eutopic endom etrial tissues in women w ithandw ithouten dometriosis via mi munohistochem istry SP method. Results GnRH was located in the cytoplasm of endometrial strom al cells and gland cells in all specmi ens. The expression of GnRH was lower in the ectopic endom etrium than that in eutopic endometrium of patientsw ith endometriosis (P 0. 05), and it was lower in the eutopic and ectopic endometrium ofpatientsw ith endometriosis than that in the endom