血管内皮生长因子及转化生长因子β联合检测在老年结核性与恶性胸腔积液中的价值.docVIP

血管内皮生长因子及转化生长因子β联合检测在老年结核性与恶性胸腔积液中的价值 　　作者：李迎莉 作者单位：210002江苏省南京市，解放军第四五四医院呼吸科 　　【摘要】 目的 监测老年结核性胸腔积液和老年恶性胸腔积液中血管内皮生长因子(VEGF)和转化生长因子Β(TGFΒ)在鉴别老年结核性和老年恶性胸腔积液中的价值。 方法 老年结核性胸腔积液组31例，老年恶性胸腔积液组30例，分别行胸腔闭式引流术。采用酶联免疫吸附法(ELISA)法检测2组患者的胸液中VEGF及TGFΒ的水平。 结果 恶性胸腔积液中VEGF及TGFΒ的水平呈正相关(r=0.438，P0.05)。恶性胸腔积液中VEGF及TGFΒ水平[(269±62)ng/L，(125.5±12.0)mg/L]较结核性胸腔积液[(104±55)ng/L，(81±23)mg/L]升高，差异有统计学意义(P0.05)。 结论 VEGF及TGFΒ在老年恶性胸腔积液的形成起重要作用，对恶性胸腔积液与结核性胸腔积液的鉴别具有重要价值。 　　【关键词】 胸腔积液 血管内皮生长因子 转化生长因子Β 　　Value of vascular endothelial growth factor and transforming growth factorΒ levels in chest fluid of older patients with malignancy and tuberculosis LI Yingli，JIANG Desheng,SHANG Ning,GU Xiaoyan.Department of Respiratory Disease，the 454th Hospital of PLA，Nanjing 210002,China 　　【Abstract】　Objective To investigate the function of vascular endothelial growth factor (VEGF) and transforming growth factorΒ(TGFΒ)levels in the pleural fluid of older patients with malignancy and tuberculosis. Methods The levels of VEGF and TGFΒ in pleural fluid of 61 older patients were measured by enzymelinked immunosorbent assay(ELISA)method. Results There was significantly positive correlation between the levels of VEGF and TGFΒ in the pleural fluid of patients with malignant pleural effusions (r=0.438,P0.05). The levels of VEGF and TGFΒ(269±62 ng/L,125±8.1 mg/L) were significantly higher in the pleural fluid of patients with malignant pleural effusions group than those in tuberculosis group(104±55 ng/L,85±12.0 mg/L)(P0.05). Conclusions These findings suggest that VEGF,TGFΒ are significant to the patient with malignant chest fluid and then may play an important role in differentiation of it from tuberculosis. 　　【Key　words】 pleural effusion; vascular endothelial growth factor; transforming growth factorΒ 　　近年来老年患者胸腔积液的发生率明显增高，结核性胸腔积液和恶性胸腔积液有时难以鉴别，因此，寻找敏感性和特异性更高的辅助诊断方法鉴别老年患者结核性胸腔积液和恶性胸腔积液有着重要意义。而肿瘤的发生发展均为血管生成依赖性。肿瘤血管生成与肿瘤的浸润转移及预后密切相关，研究表明，血管内皮生长因子(vascular endothelial growth factor