449例药品不良反应回顾性分析.pdfVIP

中国药物应用与监测2011年2月第8卷第1期 Chinese Journal of Drug Application and Monitoring, Vol.8, No.1, February 2011 449 例药品不良反应回顾性分析 孔飞飞，谭兴起，郭良君（解放军第九八医院药械科，浙江 湖州 313000 ） [摘要] 目的：了解本院药品不良反应（ADR ）发生特点及临床表现，为临床合理用药提供参考。方法：对本院2009 年1 – 12 月收集的449 例ADR 报告就ADR 上报科室、患者性别与年龄分布、既往过敏史、引发ADR 的给药途径、引发ADR 的药品 种类、ADR 的处理和预后、ADR 累及器官或系统及临床表现等进行回顾性分析。结果：449 例ADR 报告中男性307 例，占 68.37% ，女性142 例，占3 1.63% ，年龄最小为18 个月，最大为95 岁；涉及的药品（不含输液）有170 个品种，其中抗感染药 300 例次，占54.06% ，中药制剂77 例次，占16.76% ；静脉滴注的ADR 发生率最高，占77.95% ；在ADR 累及的器官中，皮肤 及其附件比例最高；新的严重的和严重的ADR 有4 1例，占9.13% 。结论：药品不良反应的发生与多种因素有关，应积极开展 ADR 监测工作，促进临床合理用药，降低ADR 发生率。 [关键词] 药品不良反应；给药途径；抗感染药物；中药注射剂；合理用药 [ 中图分类号] R969.3 [文献标识码] A [文章编号] 1672 – 8157(2011)01 – 0039 – 04 Retrospective analysis of 449 cases of adverse drug reactions KONG Fei-fei, TAN Xing-qi, GUO Liang-jun(The 98th Hospital of PLA, Huzhou 313000, China) [ABSTRACT] Objective: To investigate the characteristic and clinical manifestation of the adverse drug reactions (ADRs) in our hospital. Methods: There were 449 ADR reports collected from our hospital in 2009, which were analyzed statistically in respect of the departments, patients age and sex, previous history of allergies, routes of administration, drugs categories, consequence and prognosis, organs and systems involved and clinical manifestation. Results: Among the 449 ADR cases, 307 cases (68.37%) were male and 142 cases (31.63%) were female. The youngest patient was 18 months and the eldest was 95 years old. The 449 cases of ADR reports related to (excluding infusion) 170 species of drugs, of which 300 cases of anti-infective drugs accounted for 54.06%, 77 cases of traditional Chinese medicine inj ection accounted for 16.76%; intravenous administration had the highest incidence of ADR, accounting for 77.95%. Skin and its accessories were the most frequently affected organs by ADR. There were 4 1 new and serious ADRs. Conclusion: T