动脉僵硬指数对冠心病的预测.docVIP

动脉僵硬指数对冠心病的预测 【摘要】 目的 探讨动脉僵硬指数(arterial stiffness index, ASI)对冠心病的预测价值。方法 采用四川宇峰科技发展有限公司生产的血管硬度测量仪测量40例冠心病患者(冠心病组)与40例健康人的ASI。冠心病组根据冠状动脉造影的结果分为三个亚组：1支血管病变组(n=14)、2支血管病变组(n=16)及3支血管病变组(n=10)，分析血管病变支数与ASI的关系。结果 冠心病组与对照组的ASI值分别为124.4±22.9、88.2±15.9，冠心病组的ASI值较对照组明显增大，差异具有显著的统计学意义(P0.01)。1支血管病变组、2支血管病变组及3支血管病变组的ASI值分别为107.2±9.1、121.4±12.6、153.3±22.0，随着冠状动脉病变支数增加，ASI值也相应增加，三亚组之间ASI值比较有统计学意义(P0.05)。结论 ASI可以作为冠心病的一个新的预测指标。 【关键词】 动脉僵硬指数；冠心病；动脉粥样硬化 　　Predicting value of arterial stiffness index for coronary heart diesease 　　Chen Zhangrong, Luo Kailiang, Yin Yuehui, Hu Rong, Xiao Jun 　　(Department of Cardiology, the Second Affiliated Hospital,Chongqing University of Medical Sciences, Chongqing 400010, China) 　　ABSTRACT: Objective To investigate　the predicting value of arterial stiffness index (ASI) for coronary heart disease. Methods ASI was measured in 40 patients with coronary heart disease and 40 healthy subjects. According to the coronary arterial angiographic findings, patients with coronary heart disease were divided into three subgroups: patients with one branch of vascular disease (n=14), those with two branches of vascular disease (n=16), and those with three branches of vascular disease (n=10); the relationship between the number of diseased vessels and ASI was analyzed. Results ASI was significantly higher in coronary heart disease group than in control group (124.4±22.9 vs. 88.2±15.2, P0.01). ASI of patients with one branch of vascular disease, two branches of vascular disease, and three branches of vascular disease was 107.2±9.1, 121.4±12.6, and 153.3±22.0, respectively. ASI increased with the number of diseased vessels (P0.05). Conclusion The results suggested that ASI could be a new marker to predict coronary heart disease. 　　KEY WORDS: arterial stiffness index; coronary heart disease; atherosclerosis 　　过去对于冠心病主要关注冠状动脉粥样斑块的大小及由此引起的管腔狭窄程度。近年来认识到管腔狭窄是动脉壁病变的结果。虽然通过冠状动脉介入术和冠状动脉搭桥术是解除管腔狭窄的重要治疗手段，但早期发现血管壁的异常改变并积极干预则更为重要。冠状动脉粥样硬化是全身粥样