单唾液酸四己糖神经节苷脂治疗急性脑梗死随机双盲对照多中心研究_周盛年.pdfVIP

(Chin JNew DrugsClin Rem), 2005 11, 24 11 # 880# E-mail: xyylc shyyxx. com http: //xyyl. chinajournal. net. cn http: //zgxyylczz. periodicals. com. cn butw ith decreaseofAFP, VEGF, CD8 and increase of 67%, 40% (P 0. 05 orP 0. 01). The mi prove- CD3, CD4, CD4/ CD8 (P 0. 01). The liver func- ments of the accumulative survival rate and the quality tion except albumin mi paired, the levels of AFP, of life were conspicuous in treatment group (P VEGF increased but w ith no obviously changes of 0. 05). No decreases of the tumor mass and obvious CD3, CD4, CD8, CD4/ CD8 in the control group. adverse reactions were observed. CONCLUTION: There were significant difference bewt een the two The administration of octreotidemicrospheres for injec- groups (P 0. 01). The accumulative survival rate of tion appears to mi prove the liver function, mi munity, 3, 6, 12 mo in the control groupwere 60%, 33%, survival rate and the quality of life in patientsw ith ad- 7% and those in the treatment group were 87 %, vanced hepatocellular carcinoma. [] 1007-7669( 2005) 11-0880-04 1 1 1 1 1 2 2 3 周盛年 ,韩恩吉 ,赵庆胜 , 陈耀民,魏先森 ,万 琪,刘永红, 张 镛 , 3 4 崔元孝,马丕林 ( 1. , 250012; 2. , 710032; 3. , 250021; 4. , 250100) [] 神经节苷酯类; 脑梗死; 药物疗法; 多中 , 心研究; 随机对照试验;双盲法 ( : 2003L04330), [] 目的:评价国 单唾液酸四己糖神经节苷 , 脂钠注射液(GM 注射液) 治疗急性脑梗死的有效 , 1 性和安全性方法:本研究采用多中心随机双盲对 , 照的方法,分别给予试验组(n = 67)和对照组( n = 70)病人国 和进口GM 注射液 100mg, iv, qd, 连 1 续使用 14 d结果: 国 及进口GM 注射液对急性 1 脑梗死 NIHSS评分及 Barthel指数评分治疗前后有 显著差异(P 0. 05); 2组治疗前后NIHSS评分及 , 144, Barthel指数评分的差值及变化率组间比较无显著 : ( 1) 差异(P 0. 05)试验组在整 个试验过程中没有发