爱必妥(Erbitux)对A431移植性裸鼠模型的影响.pdfVIP

Radiotherapy and Oncology 92 (2009) 383–387 Contents lists available at ScienceDirect Radiotherapy and Oncology journal homepage: www.th Molecular radiobiology Enhanced response to C225 of A431 tumor xenografts growing in irradiated tumor bed q Oliver Riesterer a,d,*, Kathryn A. Mason a, Uma Raju a, Qiuan Yang a,e, Li Wang a, Walter N. Hittelman c, K. Kian Ang b, Luka Milas a a Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, USA b Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, USA c Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, USA d Department of Radiation Oncology, University Hospital Zurich, Switzerland e Cancer Center, Qilu Hospital of Shandong University, Jinan, China a r t i c l e i n f o a b s t r a c t Article history: Background and purpose: We recently demonstrated that C225 maintenance therapy after completion of Received 3 July 2009 radiotherapy further increased tumor radiocurability. The present study assessed mechanisms underly- Received in revised form 14 July 2009 ing the observed improvement in C225 efficacy in pre-irradiated tissue (tumor bed). Accepted 17 July 2009 Materials and methods: A431 xenografts growing in pre-irradiated and non-irradiated tissue were treated Available online 18 August 2009 with C225. Tumors were assessed for growth delay, cell proliferation, hypoxia, EGFR and VEGF expres-