急性脑卒中患者血清红细胞生成素水平改变及其的意义.docVIP

急性脑卒中患者血清红细胞生成素水平改变及其的意义 作者：赖成虹，刘信东,卢丽翔,李梦妮,李作孝 作者单位：641000成都，核工业部四一六医院神经内科 【摘要】 目的 探讨急性脑卒中患者血清红细胞生成素(EPO)水平改变及其临床意义。方法 应用放射免疫法检测60例脑梗死（脑梗死组）、45例脑出血（脑出血组）和40例其他神经系统疾病患者（对照组）的血清EPO水平。用美国国立卫生研究院卒中量表(NIHSS)对急性脑卒中患者进行评分。结果 脑梗死组和脑出血组血清EPO水平［(1.64±0.41)ng/ml，(1.59±0.54)ng/ml］显著高于对照组［(1.17±0.86)ng/ml］(均P0.05)，脑梗死组及脑出血组的NIHSS评分［（10.42±3.75）分，（11.58±4.16）分］与血清EPO水平呈负相关(r=-0.482，r=-0.537,均P0.05)。结论 急性脑卒中患者的血清EPO水平明显升高，并且病情越重的患者血清EPO水平越低。 【关键词】 红细胞生成素；急性脑卒中；脑梗死；脑出血 Change and its significance of the serum erythropoietin level in the patients with acute cerebral stroke LAI Chenghong, LIU Xindong，LU Lixiang，et al. Department of Neurology, the 416 Hospital of Nuclear Industry Department,Chengdu 641000, China Abstract：Objective To investigate the change and its clinical significance of serum erythropoietin (EPO) content in the patients with acute cerebral stroke.Methods The serum EPO content in 60 patients with acute cerebral infarction(ACI), 45 patients with cerebral hemorrhage(CH) and 40 patients with other nervous system diseases(control group) were detected by radioimmunity means. The patients with acute cerebral stroke were evaluated by National Institute of Health Stroke Scale (NIHSS). Results The serum EPO content in ACI group and CH group ［(1.64±0.41)ng/ml, (1.59±0.54)ng/ml］ were significant higher than that in the control group ［(1.17±0.86)ng/ml］ (all P0.05). The NIHSS scores of ACI group and CH group ［（10.42±3.75），（11.58±4.16）］ were negative correlated with their serum EPO content (r=-0.482， r=-0.537,all P0.05).Conclusions The serum content of EPO in the patients with acute cerebrol stroke is increased obviously. The more severe the patients condition, the lower the serum EPO content. Key words：erythropoietin; acute cerebral stroke; cerebral infarction;cerebral hemorrhage 红细胞生成素(EPO)是调节红细胞生成的糖蛋白，不仅表达于胎儿肝脏、成人肾脏，而且在非造血组织，特别是在神经组织中有广泛的表达。诸多的动物实验［1,2］证明，当脑缺氧时EPO及其受体(EPOR)在脑组织中的表达明显增加，外源EPO对多种脑损伤模型具有多层次的神经保护作用。本研究观察