电化学疗法_癌症治疗的新方法.pdfVIP

1998 6 25 145 tion of intrahepat ic cholest erol t rafficking : evi- Biodist ribution of iodine-125 tyram ine transform- dence by in v iv o antisense treatment for t he ing grow th factor alpha antisense oligonucleotide involvement of sterol carrier protein-2 in newly in athymic m ice w it h a hum an mammary tumour . . synthesized cholesterol transport into rat bile xenograft follow ing intrat um oral injection E ur J B iochem J , 1996; 17(Pt ) : 681687 N ucl M ed , 1996; 2 ( 4) :448452 15Rubenstein M , Mirochnik Y , Chou P, et al . An- 19Agraw al S, Jiang ZN, Zhao QY , et al . Mixed- tisense oligonucleotide intralesional therapy for backbone oligonucleotides as second generat ion hum an PC- prostate tumors carried in athymic antisense oligonucleotides: in v itro and in v iv o nude mice. J S urg Oncol , 1996; 62( ) : 194200 studies. P roc N atl A cad S ci US A , 1997; 94 16Bishop M R, Iversen PL, Bayever E, et al . Phase ( 6) : ( 1) 5 20 , , , . , I trial of an antisense oligonucleotide OL p Agraw al S Zhang X Lu Z et al Absorption . , 1996; in hematologic malignancies J Clin Oncol t issue distribution and in v iv o stability in rats of a 14(4) : 1 201 26 hybrid antisense oligonucleotide follow ing oral 17Roush W . Antisense aims for a renaissance. administ ration. B iochem P harmacol , 1995; 50 Sc ience , 1997; 276( 5 16) : 1192119 (4) : 571576 18 , , , . ( 1997-07-22 ) Cammilleri S Sangrajrang S Perdereau B et al : Jaroszeski MJ et al 将脉冲电场和药物化疗相结合进行癌症治疗的技术称为电化学疗法, 这种新的 治疗方案的基 是施加电场降低细胞膜的稳定性