肾苏_对局灶节段性肾小球硬化病理形态学的影响_窦一田.pdfVIP

辽宁中医杂志 2010年第 3 卷第 3期 # 551# Ò , , (天津中医药大学, 天津 300193) : 目的: 以局灶节段性肾小球硬化为研究对象, 观察辛通畅络益气和血中药复 肾苏Ò对病理形态学的影 响, 探讨中医药防治疑难疾病的有效途径 法: 采用阿霉素注射法诱发大鼠局灶节段性肾小球硬化型阿霉素肾病动物 模型, 将实验动物随机分为对照组模型组西药组和中药组于治疗后第 12周末运用光电镜, 观察各组大鼠肾脏病理 形态学变化, 半定量分析肾小球硬化积分肾小球 PAS染色阳性区面积及肾小球系膜基质相对面积结果: 病理形态观 察显示, 肾苏Ò可减轻肾脏病理损害, 抑制肾小球硬化及细胞外基质积聚, 且优于贝那普利结论:肾苏Ò对阿霉素注射 法诱发大鼠局灶节段性肾小球硬化型阿霉素肾病模型具有保护作用通过改善病理形态学变化, 达到阻抑或减缓局灶 节段性肾小球硬化进展的效果 : 肾苏Ò;局灶节段性肾小球硬化; 病理形态 : R28515 : A : 1000- 1 19( 2010) 03- 0551- 03 The Iinterventions of Shensu II About the PathologicalM odalities of Focal Segem entalG lomerulosclerosis DOU Yi-tian, GA O X ian-lou, ZH I Yong (T ianj in University of TCM, T ianj ing 300193, C ina) Abstract: Obj ective: To m ake focal segm ental glom eru losclerosis( FSGS) as the research ami , observe and discuss the effects of the renal function tests and pathologicalm odalities by the trad itional Chinese drug com plex prescrription- ShensuÒ wh ich is to dredge vessels by xintong and to comp lem ent qixue. Find the effectual modes from trad itional Chinesem ed icine to prevention and cure the d iseaseswh ich is difficult to make a diagnosis and give treatm ent.M et ods: Rat focal segm en tal glom erulosclerosis anmi al m odel is induced by injecting doxo - rubicin hydrochoride. The expermi ental anmi als are random ly d ivided into groups, the com- parison group, the d isease model group, the w estern m edicine group and the Ch inesem edicine group. A t the end of 12th w eek of treatm e