表皮生长因子受体的敲除对小鼠骨密度以及成骨细胞募集的影响.pdfVIP

34 3 ( ) Vol.34 No.3 2008 5 Journal of Jilin University ( Medicine Edition) May 2008 425 [ ] 1671587 (2008) 1 2 3 4 5 王 珂 , 李然伟 , 刘永红 , 赵燕颖 , 杨世杰 ( 1 , 130041; 2 , 130041; 3 , 130012; 4 , 130021; 5 , 130021) [ ] : ( E FR) : E FR ( E FR - / - ) , ( Masson Trichrome) , 1 : , E FR - / - ( E FR + / + ) , ; 165 ( E165) , E FR + / + ; E FR - / - E FR + / + A (Cbfa) (OC) I ( Col I) : E FR , [ ] , ; ; ; [ ] Q7; R332 [ ] A Effect of epidermal growth factor receptor deficiency on trabecular bone formation and recruitment of osteoblasts in mice 1 2 3 4 5 WAN Ke , LI Ranwei , LIU Yonghong , ZHAO Yanying , YAN Shi jie ( 1 Department of Respiratory Medicine, Second Hospital, Jilin University, Changchun 130041, China; 2Department of U rinary Surgery, Second Hospital, Jilin University, Changchun 130041, China: 3T umor Hospital of Jilin Province, Changchun 130012, China; 4Department of Physiology, School of basic Medical Sciences, Jilin University, Changchun 130021, China; 5Department of Pharmacology, School of basic Medical Sciences , Jilin University, Changchun 130021, China) Abstract: Objective T o determine the role of epidermal growth factor receptor ( E FR) signaling in bone development in mice. Methods Long bonefrom E FR wild type ( E FR + / + ) and knockout mice ( E FR - / - ) were collected and analyzed by Trichrome Masson staining, in sit u hybridization was used to observe trabecular bone formation and recruitment of osteoblasts.