67例胃腺瘤临床病理特征及免疫表型分析（英文）.pdfVIP

Chinese-German Journal of Clinical Oncology September 2010, Vol. 9, No. 9, P511–P515 DOI 10.1007/s10330-010-0665-7 Clinicopathologic features and immunohistochemical analysis of 67 gastric adenoma patients Xiuli Wang, Yangkun Wang, Yingchao Wu, Xuexia Lv, Nianlong Meng, Jian Yin, Xutao Yuan Department of Laboratory, The 150 Centre Hospital of Chinese PLA, Luoyang 471031, China Received: 19 July 2010 / Revised: 8 August 2010 / Accepted: 24 August 2010 © Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2010 Abstract Objective: The aim of this study was to investigate the clinicopathologic features of gastric adenoma. Methods: Sixty-seven cases of adenoma diagnosis of gastric biopsy specimens using light microscopy, immunohistochemistry, and follow-up methods were studied. Results: Histopathology of gastric adenoma characteristics: nuclear anaplasia, showing increase of nuclear volume and irregular, and the emergence of one or more nucleoli, mitotic ≤ 2/10 high power field (HPF). Structural changes in the gland: adenoma of the duct much more consistent, sometimes the size of the gland and irregular contour, might be associated with intestinal metaplasia. Increased significantly when the nuclear volume, mitotic 2/10 HPF, irregular gland distortion, branched structures, suggesting the development of adenomas. Immunophenotype: tumor-associ- ated carbohydrate antigens had a higher expression; adenomatous polyposis coli gene (APC) and carcinoembryonic antigen (CEA) expression of closely related with the formation of adenoma. Mucin muc-2 high expression was negatively correlated with muc-1 low expression, the combination of both can help to determine the development and changes in gastric adenoma.