137例MAID方案一线化疗转移软组织肉瘤的回顾性临床分析（英文）.pdfVIP

Chinese-German Journal of Clinical Oncology February 2012, Vol. 11, No. 2, P117–P120 DOI 10.1007/s10330-011-0887-3 Retrospective clinical analysis of MAID protocol as first-line treatment on 137 metastatic soft-tissue sarcomas patients Kun Han, Yuanjue Sun, Jianjun Zhang, Lina Tang, Shui’er Zheng, Zhiyu Wang, Hui Zhao, Feng Lin, Zan Shen, Yang Yao Department of Medical Oncology, The Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, China Received: 11 August 2011 / Revised: 20 September 2011 / Accepted: 23 October 2011 © Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2012 Abstract Objective: The aim of this study was to evaluate the efficacy, adverse reaction and survival of MAID protocol as first-line treatment on 137 metastatic soft tissue sarcomas patients. Methods: One hundredand thirty-seven patients with metastatic soft tissue sarcoma were given MAID protocol chemotherapy which consists of ifosfamide at a total dose of 8–10 g/m2 2 2 in 4–5 days, adriamycin at a dose of 60 mg/m on first day and dacarbazine at a dose of 200 mg/m /d in 4–5 days. Twenty one days were regarded as a cycle and 2-6 cycles were completed. The median cycle number was 4. Results: Four cases had complete remission (CR) (2.9%), thirteen cases achieved partial remission (PR) (9.5%), eighty-eight cases maintained a stable disease (SD) (64.2%), and thirty-two cases had progressive disease (PD) (23.4%). The overall response rate (RR) was 12.4%, disease control rate (DCR) was 76.6%. The progression-free survival (PFS) was 2–14 months and median PFS was