《Aquaporin 4 expression and ultrastructure of the bloodbrain barrier following cerebral contusion injury》.pdfVIP

NEURAL REGENERATION RESEARCH Volume 8, Issue 4, February 2013 doi:10.3969/j.issn.1673-5374.2013.04.006 [; ] Li XJ, Han YY, Xu H, Sun ZS, Zhou ZJ, Long XD, Yang YM, Zou LB. Aquaporin 4 expression and ultrastructure of the blood-brain barrier following cerebral contusion injury. Neural Regen Res. 2013;8(4):338-345. Aquaporin 4 expression and ultrastructure of the blood-brain barrier following cerebral contusion injury★ 1 1, 2 1 1 1 1 Xinjun Li , Yangyun Han , Hong Xu , Zhongshu Sun , Zengjun Zhou , Xiaodong Long , Yumin Yang1, Linbo Zou1 1 Department of Neurosurgery, Deyang People’s Hospital, Deyang 618000, Sichuan Province, China 2 Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China Abstract This study aimed to investigate aquaporin 4 expression and the ultrastructure of the blood-brain Xinjun Li★, Master, Attending physician. barrier at 2–72 hours following cerebral contusion injury, and correlate these changes to the formation of brain edema. Results revealed that at 2 hours after cerebral contusion and laceration Corresponding author: injury, aquaporin 4 expression significantly increased, brain water content and blood-brain barrier Hong Xu, Master, Chief physician, Department of permeability increased, and the number of pinocytotic vesicles in cerebral microvascular endothelial Neurosurgery, Deyang cells increased