《ArgPheamiderelated peptides influence gonadotropinreleasing hormone neurons》.pdfVIP

NEURAL REGENERATION RESEARCH Volume 8, Issue 18, June 2013 doi:10.3969/j.issn.1673-5374.2013. 18.009 [; ] Kelestimur H, Kacar E, Uzun A, Ozcan M, Kutlu S. Arg-Phe-amide-related peptides influence gonadotropin-releasing hormone neurons. Neural Regen Res. 2013;8(18): 1714- 1720. Arg-Phe-amide-related peptides influence gonadotropin-releasing hormone neurons*● 1 1 2 3 1 Haluk Kelestimur , Emine Kacar , Aysegul Uzun , Mete Ozcan , Selim Kutlu 1 Department of Physiology, Medical School, Firat University, Elazig, Turkey 2 Department of Biochemistry, Medical School, Karadeniz Technical University, Elazig, Turkey 3 Department of Biophysics, Medical School, Firat University, Elazig, Turkey Abstract The hypothalamic Arg-Phe-amide-related peptides, gonadotropin-inhibitory hormone and Corresponding author: Haluk Kelestimur, Professor, orthologous mammalian peptides of Arg-Phe-amide, may be important regulators of the Department of Physiology, hypothalamus-pituitary-gonadal reproductive axis. These peptides may modulate the effects of Medical School, Firat kisspeptins because they are presently recognized as the most potent activators of the University, Elazig 23119, Turkey, hypothalamus-pituitary-gonadal axis. However, their effects on gonadotropin-releasing hormone hkelestimur@.tr. neurons have not been investigated. In the current study, the GT1–