二妙胶囊和二妙丸的药代动力学比较_周凌.pdfVIP

# 246# Journal of Ch ineseM ed icinalM aterials 33 2 2010 2 二妙胶囊和二妙丸的药代动力学比较 周 凌, 孙兆姝, 窦德强, 曹爱民, 康廷国 (辽宁中医药大学药学院, 辽宁 大连 116600) : , : , HPLC, - DAS 210, : , 010043~ 01427 L g/mL, , RSD 10% , 01 082 Lg /mL, 8 h; 01 303L g/mL, 5 h: HPLC , , ; ; ; : R 28515 : A : 1001-4454( 2010) 02-0246-04 Comparation of Pharm acok in etics abou t E rm iao Capsules and E rm iao Pellet ZHOU L ing, SUN Zhao-shu, DOU De-q iang, CAO A-im in, KANG Ting-guo ( L iaon ing Un iversity of TCM, Dalian 116600, Ch ina) A bstrac t Objective: To compare the pharm acok inetics about E rm iao capsules and Erm iao pellet, and observe the changes in plas- m a concentrationw ith d ifferent form ulations in an mi als from the perspective of pharm acok inetics1 M ethods: A fter the rabbits w ere ad- m inistratered w ith E rm iao capsu les and Erm iao pellet through ig1 H PLC was used to determ ine berberine in blood p lasm a at d ifferent tmi es, DAS 21 0 procedurew as used to process concentration-tmi e data1 Results: In the rabbit p lasm a samp les, the linear range of ber- berine w as 0100427~ 01427 Lg /mL, it has a high extract recovery rate, and day-day precision RSD w as less than 10% 1 The whole b lood concentration-tmi e course of berberine in Erm iao capsu lesw as fitted to be a two-compartm entm odel, and berberine in E rm iao pe-l let w as fitted to be a one-com partm ent model1 Conclusion: Th is essay estab lishes a method for determ ine berberine in rabb it p lasm a, provided the pharm a cok inetic param eters for rational adm in istration of E rm iao capsules, and also provided the pharm acok inetic study m ethod of compounds1 K ey w ord s E rm iao capsu les; E rm iao pellet; Berberine; Pharm acok inetics , , ,