复方银黄微型灌肠剂家兔体内药代动力学研究.pdfVIP

31 1 中国 中药杂 志 Vol131, Issue 1 2006 1 China Journal of Chinese Materia Medica January, 2006 2. The Second People. s H ospital of Banan, Chongqing 400054, China) [Abstract] Objective: To study the effects of total alkaloids(TA) from rhizoma Cop tis chinensis on alcoho-l induced gastric lesion in rats and the possible mechanisms. Method: The e perimental gastric damges were established by intragastric( ig) absolute ethanol, and possi- ble protective effects of TA given orally previously were evaluated by following parameters: gastric damage inde es, gastric juice volume, acidi- ty, and mucus quantity. The contents of NO, MDA, #OH, and SOD activity were also measured in gastric mucosa. Result: TA showed sig- nificantly inhibitive effects on gastric damages induced by ig ethanol in a dose dependent manner. The effects of TA( 120 mg# kg- 1) were stronger than that of both cimitidine( 70 mg#kg- 1) and berberine( 100 mg#kg- 1) , the quantity of later was equal to TA as calculated with berberine. TA significantly suppressed secretion of gastric acid caused by ethanol without clear influences on gastric juice volume and mucus secretion. TA obviously blunted ethanol-induced elevation of MDA and #OH, as well as decrease of NO level and SOD activity from gastric mucosa. Conclusion: It is suggested that the TA is a potent protective agent against ethanol-induced gastric damages. The mechanism of ac- tions may be related with inhibiting the secretion of gastric acid and blunting the increase of MDA and #OH, as well as the decrease of NO level and SOD activity from gastric mucus. [Key words] total alkaloids from Cop tis ; ethano-l induced gastric lesion; rats [ ] 秦三海, 刘华钢* ( 广西医科大学 药理教研室, 广西 南宁530021) [ ] : , : , 3P97 , : , : t1/ 2A 01311 h, t1/