外源性透明质酸应用于伤口愈合中的生化分析.pdfVIP

Acad J Sec Mil Med Univ1998 A u ; 19( ) 8587 85 △ 吕　洛　冷永成 　陈玉林 ( ) 45 , , 目的: HA 方法: SD 2% HA ( A ) 1% HA ( B ) PBS ( C ) , , ; ( Hyp) ( PC ) 结果: ( 1) 3 ( 15. 22. 0) , ( 14. 21. 6) ( 13. 41. 4) d, A B C (P 0. 05) A B C , 3 ( 0. 05) ( 2) : ( 0. 0 1) , P Hyp P C A B Hyp C P PC C (P 0. 01) ( 1) HA , , , 结论: ( 2) HA ; ; ; ; R644. 05 A biochemical study in wound healing with exogenous hyaluronic acid L™Luo, Len Yon chen , Chen Yulin ( Department of Burn, Chan hai Hospital, Second Military Medical U niversity, Shan hai, 200433) AbstractObj ective: T o evaluate the effects of hy alur onic acid( HA ) on the inhibition of scar formation . : - and their possible mechanism s Methods Forty five healthy adult SD rats in a dorsal part tr auma model w er e randomly divided into 2% HA treated- roup ( r oup A ) , 1% HA tr eated- r oup ( roup B) , and PBS treated- roup as a control roup ( roup C) . The pr ocess of healin w as observed, the remained w ound area w as measured, and mean wound healin time w as calculated. Furthermore, dynamic analysis of local , . : ( 1) tissue protein Hyp and PC contents w as performed Results T he r emained w ound area of contr ol r oup w as much smaller than that in treated roup, and the mean value of w ound healin time w as( 15. 2 2. 0) , ( 14. 21. 6) and ( 13. 41. 4) d, respectively . ( 2) T he contents of tissue Hyp w ere statistically low - - , . : er in HA tr eated roups w hile those of PC w ere statistically hi her as compar ed w ith Conclusion ( 1) The exo enous hy aluronan can eff