小剂量阿托伐他汀联合非诺贝特治疗混合型高脂血症临床观察.pdfVIP

· 药物与临床 · 2011年3月第49卷第8期 小剂量阿托伐他汀联合非诺贝特治疗混合型高脂血症临床观察 王伯成 (浙江省新 昌县新康医院心内科，浙江新 昌312500) 【摘要】目的 探讨小剂量阿托伐他汀联合非诺贝特治疗混合型高脂血症的疗效及安全性。方法 选取混合型高脂血症患者 148例，随机均分为2组，观察组晨起El服非诺贝特 100mg，晚上服用阿托伐他汀 10mg；对照组每晚服用阿托伐他汀20mg。 疗程均为8周。观察患者血脂水平变化及不 良反应发生情况。结果 观察组TC、TG、LDL—C明显降低 (P0．05)，HDL—C明 显升高(P0．05)；对照组TC、LDL—C明显降低 (PO．05)。与对照组比较，观察组TG水平明显降低 (PO．05)，HDL-C水 平明显升高 (P0．05)。观察组与对照组临床总有效率分别为79．7％、62．2％(P0．01)。两组不良反应发生率无统计学差 异。 结论 小剂量阿托伐他汀联合非诺贝特治疗混合型高脂血症疗效较好，不 良反应发生率低。 【关键词】阿托伐他汀；非诺贝特；混合型高脂血症 【中图分类号】R589．2 [文献标识码】B [文章编号】1673—9701(2011)08—56一O2 CHnical Studies on Low—dose Atorvastatin and Feno丘brate for the TreatmentofCombined Hyperlipidemia WANG Bocheng DepartmentofCardiology，XinkangHospitalofXinchangCountyinZh~iangProvince，Xinchang312500，China IAbstract】ObjectiveTostudytheefficacyandsafetyoflow—doseatorvastatinandfenofibrateforthetreatmentofcombinedhyper- lipidemia．Methods 148 patientswith combined hyperlipidemiawererandomly divided into two groups．Theobservation group was treated wiht oral100 mgoffenofibratein the morning，with 10 mg ofatorvastatin in theevening．Thecontrolgroup took20 mgofa— torvastatin every night．Th e treatmentlasted 8 weeks．Changesin blood lipid levelsnad incidence ofsideeffectswereobserved．Re- suitsTC，TG，LDL-Clevelsdecreasedsignificantly(P0．05)，andHDL-ClevelWas significnatlyhigherintheobservationgroup(P 0．05)。TC，LDL-Cdecreasedsignificantlyinthecontrolgroup (P0。05)．Comparedwiththecontrolgroup，TG levelwassignificnatly lower(P0．05)，nadHDL—C levelwassignificantlyhigherinhteobservationgroup (P0．05)．Thetotaleffectiveratesofobservation groupandcontrolgroupwere79．7％ and62．2％ respectively (P0．01)．The incidencesofadversereactionsbetween thetwogroups had no singificna tdifferences．Conclusion Low-dose atorvastatin and fenofibrate forthe treatmentofcombin