麝香祛痛气雾剂的抗炎镇痛作用与毒理学考察.pdfVIP

1212 2007 27 9 Chin Hosp Pharm J, 2007 Sep, Vol 27, o. 09 1 1 2 2 2 ( 1. , 4 30 02 2; 2 . 师少军, 李忠芳 , 汤凌燕 , 陈汇, 曾繁典 , 430 03 0) [ ] :研究麝香祛痛气雾剂局部给药的抗炎镇痛 用及毒性反应: 用二甲苯致小鼠耳肿胀和角叉菜胶致大鼠 足跖肿胀,考察麝香祛痛气雾剂的抗炎 用; 用小鼠醋酸扭体法和热板法, 观察麝香祛痛气雾剂的镇痛 用观察家兔一次 性局部给药的急性毒性和皮肤刺激性,观察豚鼠给药的皮肤致敏性: 麝香祛痛气雾剂局部皮肤给药, 可明显减轻小鼠 耳肿胀度, 降低角叉菜胶致大鼠足跖肿胀; 对小鼠醋酸扭体和热板反应均呈剂量相关性镇痛 用; 对家兔和豚鼠无明显急性 毒性反应刺激性和致敏 用: 麝香祛痛气雾剂局部给药, 具有明显的抗炎镇痛 用,无明显毒性刺激性和致敏性 [ ] 麝香祛痛气雾剂;抗炎; 镇痛;毒理学 [ ] R285. 6 [ ] A [ ] 1001-52 13( 2007) 09-12 12-03 Study on ant-i inflammatory and analgesic effects and toxicity of Moschus analgesic aerosol 1 1 2 2 2 SH I Shao-jun , LI Zhong-fang , TA G Ling-yan , CHE Hui ,ZE G Fan-dian ( 1. Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and T echnology, Hubei Wuhan 4 30022 ,China; 2 .Institute of Clin-i cal Pharmacology, Tongji M edical College, Huazhong University of Science and Technology,Hubei Wuhan 43 0030 ,China) ABSTRACT:OBJECTIVE To study the ant-i inflammatory and analgesic effects and toxicity of M osch us analgesic aerosol ( MAA) . MET ODS Models of acute inflammatory reactions of xylene-induced mice ear edema and carrageen-induced rats paw edema were performed to study the ant-i inflammatory effects. Methods of acetic acid- induced writhing and hot-plate test in mice were used to study the analgesic effect. The acute cutaneous toxicity and cutaneous stimulation and hypersensitivity were per- formed in rabbits and guinea pigs. RESULTS MAA significantly suppressed xylene- induced mice ear edema and carrageen-in- duced rats paw edema. Thewrithing times of mice induced by acetic acid were decreased and pain threshold was remarkably im- proved by MAA in dose-dependent manner.MAA had no acute toxicity,no cutaneous stimulation and no hypersensitive effects for the intact or damaged skin in rabbits and guinea pigs.CONCLUSION