中药量效关系特征问题的探讨_范欣生.pdfVIP

• 270 • ( ) 中华中医药杂志 原中国医药学报 2009年3 月第24卷第 3期 CJTCMP , March 2009, Vol . 24, No.3 ·论著· 中药量效关系特征问题的探讨* 范欣生，段金廒，王中越，姚映芷 （南京中医药大学江苏省方剂研究重点实验室，南京 210046） 摘要：中药的量效关系，尤其是在方剂复杂体系中显现的量效关系，是中医药现代化中需要深入研究的重 要问题。作者对中药量效关系认识及其基本特征进行探讨，认为中药的量效关系除具有一般药物所共有的属性， 又具有基于整体观的用药规则、基于七情和合配伍形成的非线性量效特点、基于量效改变而致配伍关系变化的多 重疗效特点等中医药鲜明特征。中药量效关系的研究既包括单味药，也包括药对、方剂的量效关系的研究。量效 关系研究将有可能从概念与科学内涵、思路与方法等方面进行系统阐述，这将为基于临床实践经验积累的中药及 方剂量效关系赋予现代依据，为中医用药规范、合理用药、提高临床疗效提供指导，为中药创新药物研究提供基 础，也必将为中医药现代化水平的提高做出应有的贡献。 关键词：量效关系；非线性；配伍；中药；方剂 On characteristic properties of TCM dose-effect relationship FAN Xin-sheng, DUAN Jin-ao, WANG Zhong-yue, YAO Ying-zhi (Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046，China) Abstract: The relationship of dose and effect in TCM formulae was an important subject in the TCM modernization research. Some characteristic properties of TCM dose-effect relationship were proposed in this paper: the dose-effect relationship of TCM had a specifi c regulation from the whole-view idea in traditional medical theories besides common properties, nonlinear character from the compatibility of medicine properties, and multi-effects varied with the different compatibility from the alternation of doses. The subjects of dose-effect relationship included single medicine, drug pair and formulae. The study on the dose-effect relationship of TCM might be helpful to the explanation of conception, connotation, ideas and methods of TCM, provide scientifi c supports and instructions for the TCM clinical practices, and provide research bases for the TCM innovation.