磷酸二酯酶抑制剂的药理及临床应用进展.pdf

464 安 徽 医 药 Anhui edical and Pharmaceutical Journal 2006 Jun; 10 ( 6) 磷酸二酯酶抑制剂的药理及临床应用进展 , (浙江省湖州市第一人民医院药剂科, 浙江 湖州 313000) : , , , , , : ; ; ; Pharm acology and application progress of the phosphodiesterase inhibitor LIX iaom ing, HU A ihong (D epartment of Pharmacy, TheFirstPeople sH osp ita,lH uzhou, Zhejiang Province 313000, China) A bstrac t: The au thors have done the research b consu lting the relative dom estic phosphodiesterase inh ib itor literature pub lished in re cent ears. A ttempts have been made to know the statws quo of the phosphodiesterase inhibitor clin ical practice in recent ears. An anal sis of its functionalm echan ism has been m ade, for further developm ent. The researches show that phosphod iesterase inh ib itor has d ifferent functions in clinical practice because of phosphodiesterase isoenz m e t pe difference, distribution difference and selective difference, etc. Selective phosphod iesterase inh ib itorm a be used to treatm an kinds of d iseases, and has been the hot spot in being app lied to de velop ing card iac agen ts, vasod ilatation m ed icine, m usclesm oothing d iastole m edicine, antiasthm atic m edicine, anti despondent m edi cine, etc. K ey w ord s: phosphodiesterase inh ibitor; selectivit ; heart failure; sexual mi potence [ 1] ( PDEs) 11 , , PDE , 3 PDEs, , , , PDE ( P ) ( V ) 3 ES E S , , ( dp /dtmax) ( VED) ( SW ) , ; VED , , PDE