复方苦参注射液联合顺铂胸腔灌注治疗恶性胸水的疗效观察.pdfVIP

复方苦参注射液联合顺铂胸腔灌注治疗恶性胸 水的疗效观察 林思祥”，王义善，丛晓玲(中国人民解放军107医院全军肿瘤诊疗中心，烟台市264002) 中图分类号R979．1 文献标识码B 文章编号1672—2124(2007)06—0465—02 摘 要 目的：为提高患者激活自身免疫细胞抗肿瘤活性，且杀灭胸水癌细胞的作用，达到减少恶性胸水及减轻患者痛苦的目的。 方法：确诊为恶性胸水的患者共66例，随机分成两组，即复方苦参注射液、顺铂联合用药组与顺铂组，每组33例。两组患者在胸 腔穿刺抽液后，分别注入不同药物处理，比较两种处理方法对消胸水灌注药物次数有无差剐。结果：两组患者消胸水用药灌注次 数及不良反应有差别(P0．05)。复方苦参注射液、顺铂联合用药灌注组优于单纯顺铂灌注组。结论：复方苦参注射液、顺铂联 合用药对激活免疫细胞抗肿瘤活性、杀灭癌细胞，促进胸膜粘连，既达到减少恶性胸水，又有提高患者抗病能力的作用。 关键词 复方苦参注射液；顺铂；胸腔灌注；恶性胸水 ThoracicPerfusionof Plus for PleuralFluid CisplatinMalignant CompoundKuhsengInjection LIN Tumor andTreatment Yishan，CONG(PLA Sixiang，WANG Xiaoling Diagnosis ofPLA，Yantai264002，China) Hospital ABSTRACT activate andkill cellsin OBJECTIVE：To patients’auto～immunocytes’anti—tumoractivity malignant fluidSOastoreducetheamountof fluidandrelieve totalof66cases pleural malignantpleural patients’pain．METHODS：A whohadbeen as fluidwere toreceive diagnosed malignantpleural randomlyassigned compoundKuhsengInjection having thoracic thoracentesisand alone(control pluscisplatin(trialgroup，n=33)orcisplatin group)by following Perfusion the in fluidandthe timeswere were aspiration，thenefficacypleural dmgperfusion compared．RESULTS：Theresignificant differencesbetweentwo the in fluidandthe timesaswellas groupsefficacypleural dmgperfusion trial better thanincontrol groupshowingimprovement