FOLFOX4方案一线治疗晚期大肠癌近期疗效分析.pdf

·128· FOLFOX4方案一线治疗晚期大肠癌近期疗效分析 王凤庭，郑红霞 (曲靖市第一人民医院肿瘤科，云南曲靖655000) 85 摘要：目的 观察FOLFOX4方案一线治疗晚期大肠癌的近期疗效和毒副反应。方法32例晚期人肠癌给予OXAmg／m2静脉 400 400 滴注2h，d。，CF mg／m2静脉滴注2h，5-Fumg／m2静脉推注后以600mg／m2持续滴注22h，d12。每2周重复为1个周期。4 个月。骨髓抑制为主要毒副反应，粒细胞减少发生率达75．O％，其次是胃肠道反应和周围神经毒性。结论FOLFOX4方案一线治 疗晚期大肠癌疗效较好，毒副反应可以耐受。 关键词：晚期大肠癌；化学治疗；FOLFOX4 中图分类号：R730．53；R735．3+4文献标识码：A 文章编号：1673—5412(2009)02—0128—02 ofShort．TermEffectsofFOLFOX4asFirst．LineTreatmentonAdvancedColorectal Analysis WangFengting，ZhengHongxia First (DepartmentofOncology，thePeople’sHospitalofQujing，Qujing655000，China) Theshort—term and ofFOLFOX4wereevaluatedfor withadvancedcolorectalcarcino— Abstract：Objectiveefficacytoxicity treatingpatients maasthefirst·line 85 infusionfor2 400 infusionfor2hoursfoHowed chemotherapy．MethodsOxaliplatinmg／m2 hou碍，dl，CFmg／m2 by 4-6 5一Fu400 ivbolusand600 infusionfur22 twoweekswerea wereevaluatedafter mg／m2 me／m2 hours，d，．2，Every cycle．Thepatients 32 whowere 9 enteredthis total ratewas thedis— cycles．Resultspatients experiencedcyclesaveragely study：theresponse 50．O％．and easecontrolratewaB90．6％．Mediansurvivaltimewas8．5months．Themainadve瑙eeffectswere was FOLFOX4wageffectiveforthefirst—line of 40．6％．Conclusion 75．O％，nausea／vomiting53．1％，neurosensorytoxicity chemotherapy advancedcolorectal the wasmildandtolerable． carcinoma，andtoxicity coloreetal words：advanced Key carcinoma；chemotherapy；FOLFOX4 2005年10月至2