烧伤创面内表皮生长因子与表皮生长因子受体蛋白变化的临床研究.pdfVIP

表达次之；在创面已经愈合部位 EGF 蛋白和 EGFr 蛋白表达相对减弱；正常皮肤对照部位 EGF 蛋白和 EGFr 蛋 白无明显的表达。结论：烧伤创面内不同部位 EGF、EGFr 蛋白的表达强度和分布情况不同，其变化与创面愈合 密切相关，提示创面内源性的 EGF、EGFr 蛋白表达变化在促进创面愈合方面有很重要的作用。 关键词：烧伤创面 表皮生长因子 表皮生长因子受体 免疫组织化学 TheclinicstudyontheendogenouschangesofEGFandEGFrintheburnwound Gu ting-min,,sui zhi-fu,zhao zhi-li,et al,. The centre of laser dermatology cosmetics and plastic surgery of General Hospital of Beijing Military Command.100700 Purpose Purpose Abstract: PPuurrppoossee:To observate the change and the distribution of endogenous epidermal growth factor(EGF) and Method Method epidermal growth factor recepter(EGFr) in the burn wound and their effects on the wound healing.MMeetthhoodd: The immunohistochemistry stainning method is used to detect the expression of EGF and EGFr in the different parts of burn Results Results wound in 35 patients.RReessuullttss:there are more remarkably expression of EGF and EGFr in the margin part between the granulation part and the healed part of the burn wound and with obviously expression of EGF and EGFr in the center granulation part and with slightly expression of EGF and EGFr in the healed reepithelization part of the Conclusion Conclusion wound.CCoonncclluussiioonn:The changes of endogenous EGF and EGFr in the burn wound are closely related to the wound healing and which may have an important role effects on wound healing. Key words: Key words: KKeeyywwoorrddss::burn wound epidermal growth factor receptor epidermal growth factor immunohistochemistry 创面愈合过程涉及了机体全身和局部的许多病理变化。我们曾报道过人和大鼠供 皮区创面愈合过程中内源性表皮生长因子、表皮生长因子受体有明显的表达，并表明其与组织修复有明显的关系， （ 、 、 ） 1 2 3 。为探讨其变化的普遍意义，我们对临床烧伤创面内的 EGF、EGFr 变化进行了观察，报道如下。 1 1 11 资