口腔鳞癌发展过程中抑癌基因PTEN的蛋白表达及意义_周传香.pdfVIP

2003 10 19 5 365 PTEN * 周传香 高文信 魏秀峰 ( 吉林大学口腔医学院口腔颌面外科 吉林长春 130041 ) [ ] : PTEN( phosphatase and tensin homologue deleted on chromosome ten) (oral squa mous cell cancer, OSCC) : S P 10 10 15 32 OSCC PTEN , :PTEN ; PTEN 93. 3% ; OSCCPTEN 71.9% , OSCC PTEN 85.7% 75% 33. 3% PTEN OSCC , : OSCC ( ) PTEN , PTEN OSCC [ ] PTEN; ; OSCC; [ ] R781. 5 R780.2 [ ] A [ ] 1671) 7651(2003) 05) 0365) 03 Expression and Significance of Tumor Suppressor Gene PTEN in the Transformation of Oral Squamous Cell Cancer. ZH OU Chuan xiang, GAO Wen xin, WEI Xiu f eng. H osp ital of Stomotology , Jilin Uni ersity , Changchun 130041 [ Abstract Objective:To investigate the protein expression of tumor suppressor gene PTEN in the transformation of oral squamous cell cancer(OSCC) and its clinicopathological significance.Methods:PTEN protein expression in paraffin embedded tissues from 10 cases of normal oral mucosa, 10 cases of oral epithelial hyperplasia, 15 cases of oral epithelial dysplasia and 32 cases of OSCC was analysed by immunohistochemical method. Results:Normal oral mucosa and oral epithelial hyperplasia tissues were all positive for PTEN protein .In the tissues from oral epithelial dysplasia, 93. 3% were positive for PTEN protein . In the tissues from OSCC, 71.9% were positive for PTEN protein.PTEN protein expression did not show correlation to sex and age, but there was a signifi cant difference between well differentiated OSCC( 85. 7% PTEN positive) and poorly differentiated OSCC (33. 3% PTEN posi tive) . Conclusions:The higher incidence of negative expression of PTEN protein in OSCC indicates that PTEN gene inactivation may play an important role in the genesis and development o