基于功效和物质基础的补骨脂毒性研究进展.pdf

中国药物警戒第11卷第8期 2014年8月 August,2014,Vol.11,No.8 中图分类号：R282.71 ；R285.5 文献标识码：B 文章编号：1672-8629（2014 ）08-0482-03 ·综述· 基于功效和物质基础的补骨脂毒性研究进展 1-2 1* 1 2 赵庆华 孙蓉 （山东省中医药研究院，山东济南250014；山东中医药大学，山东济南250355） 摘要：目的 为明确补骨脂的功效和毒性物质基础、功效和毒性的相关性以及为今后安全标准制订和进行功效物质 基础下补骨脂的毒性研究提供文献依据和研究思路。 对文献古籍中对补骨脂毒性的记载及近十几年来补骨脂 方法 国内外相关文献报道进行整理、分析与归纳。结果 历代古籍对补骨脂毒性记载甚少，现代研究仅局限于补骨脂药 理、毒理、化学成分等独立性研究，缺少其功效、毒性、物质基础三者关联性研究。因此，应依托功效和物质基础，制订 完善的补骨脂安全使用标准，使其毒性可被科学控制。结论 只有在补骨脂功效表达和功效物质基础分离与控制的 过程中，进行毒性的研究和毒性物质基础的安全控制，才能提出切合补骨脂临床使用过程中药品不良反应的预警方 案和早期诊疗措施，确保补骨脂临床用药安全。 关键词：补骨脂；功效；物质基础；毒性 Research Development on Toxicity of Psoralea corylifolia L. Related to Efficacy and Chemical Material Basis 1,2 1* 1 2 ZHAO Qing-hua SUN Rong ( Shandong Research Academy of TCM, Shandong Jinan 250014, China; Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355, China) Abstract: Objective To provide literature evidence and research ideas for determining the correlation of efficacious and toxic substance basis as well as the correlation of its efficacy and toxicity of Psoralea corylifolia, making safety standards, and studying its toxicity based on its efficacious substance basis. Methods References in old days and last decades at home and abroad about Psoralea corylifolia were collated, analyzed and summarized. Results The references in old days were lacking in the records of toxicity of Psoralea corylifolia. The recent researches were confined to the isolated aspect such as pha