滑膜肉瘤组织VEGF和PDGFR_表达临床意义的研究_王桂臣.pdfVIP

2009 11 1622 CH IN J CANCER PREV TREAT , November 2009, V ol. 16 No. 22 # 1801 # ×临床基础研究Ø VEGFPDGFR-A 王桂臣, 孙保勇, 李敏 山东省肿瘤医院骨软外科, 山东 济南250117 Expression and Significance of vascular endothelial growth factor and platelet-derived growth factor alpha receptor in synovial sarcoma tissues WA NG Gui-chen, S UN Bao-yong, LI Min Dep artment of Bone and Sof t Tissue Surgery , Shandong Tumor osp ital, J inan 250117, P.R. China = : 探讨滑膜肉瘤组织中血管内 [ ABSTRACT] OBJECTIVE: To etermine the role of vascular en- 皮生长因子( VEGF) 血小板衍生生长因子 othelial grow th fact or ( VEGF) an platelet- erive grouth factor A 受体 ( PDGFR-A) 的 达与肿瘤血管形成 alpha receptor (PDGFR-A) in synovial sarcoma. METHODS: Im- 的情况及其临床意义: 采用免疫组 munohistochemical metho was use to etect the expressions of 化SP 法分析 34 例原发性滑膜肉瘤组织 VEGF, PDGFR-A, an factor Ø in 34 cases of primary synovial VEGFPDGFR-A 的 达情况, 检测Ø因子 sarcoma. The microvessel ensity ( M VD) w as etecte by using 以计算微血管密度( M VD) : 滑膜肉 factor Ø. RESULTS: The expression rates of VEGF an 瘤组织中VEGF 和 PDGFR-A 达率分别 PDGFR-A in synovial sarcoma were 61. 76% (21/ 34) an 55. 89% 为 61.76 % ( 21/ 34) 和 551 89% ( 19/ 34) ; 两 ( 19/ 34) respect ively. The coexpression rate was 381 24% ( 13/ 34) . 者共同阳性 达率为 38. 24% ( 13/ 34 ) The VEGF an PDGFR-A w ere statistically relate w ith the MVD, VEGFPDGFR-A 与滑膜肉瘤的分级分期 gra es, progression an prognosis of synovial sarcoma ( P 和预 后相关, 并与 MVD 呈正相关, P 01 05) . They w ere also relate w ith each other (P 01 05) . CON- 01 05此外, 两者之间也有相关性, P CLUSI ONS: T he VEGF an PDGFR-A can up regulate the mi- 01 05: VEGFPDGFR-A 能共同调节 crovessel format ion in synovial sarcoma simultaneously. T hey can 滑膜肉瘤的血管形成, 可用于判断滑膜肉瘤