多肿瘤标志物蛋白芯片检测系统在肺癌诊断中de临床评价.pdfVIP

生 ! 筮 !鲞筮 ! MODERNONCOLOGY，Ju1．2011。VOI．19，NO．7 · 1345 · 多肿瘤标志物蛋白芯片检测系统在肺癌诊断中的临床评价 陈亚楠 ，王士祺 ，斯晓明 ，刘文超 Clinicalapplicationandtheresearchprogressofmultipletumormarkerproteinchipde— tectionforlungcancer CHEN Ya—nan ，WANGShi—qi，SIXiao—ming ，LIU Wen—chao DepartmentofOncology，XijingHospital，TheFourthMilitaryMedicalUniversityXian710032，China；XijingHospitalofDigestive Diseases，Th eFourthMilitaryMedicalUniversity 在n710032．China． A【bstract】 Objective：Toinvestigatethediagnosticvalueofmuhi—tumormarkersproteinbiochipdetectivesystem inthediagnosisoflungcancer．Methods：Onehundredandseventeenpatientswithlungcancer(1ungcancergroup) andfivehundredandsevenpatientswithothercancer(controlgroup)werestudied．SerumCEA，AFP，CA125，CA15 — 3，CA19—9，CA242，Ferrweremeasuredwiththemulti—tumormarkersproteinbiochipdetectivesystem．Thelev． elsofthemarkersabovewerecomparedbetweenthelungcancergroupandcontrolgroup．ThosewithaPvalueof O．1wereenteredintoamultivariateanalysis．Thenthereceiversoperatingcurve(ROC)wasperformedtodetemrine htecut—offvalueofeachindependentparameteroflungcancer．ThediagnosticvalueofeachmarkersWaScompared usingtheareaunderthecurve(AUC)．Results：ThelevelsofCA19—9，CEA，CA242，Ferr，B—HCG，AFP，Free— PSA，PSA，CA125andCA15—3inlungcancergroupwerehigherthanincontrolgroup(P0．O1)．Multivariatea— nalysisdemonstratedthattheCEA．FerrandCA153wereindependentmarkersoflungcancer．Th eoptimum cut一0ff valuesofCEA，FerrandCA153were0．39，2．06，0．96．AUCswerecompraedbyMedealc@ version11．4．4．0and hteresultindicatedthattheAUCsofFerrandCEAwerelargerthantheAUCofCA125(P0．05)．Cond~ion： CEA，FerrandCA153wereindependentparametersinthediangosisoflungcna cer．Amongthem，FerrandCEA weresuperiortoCA153inthediangosisoflungcancer． K【eywords】tumormraker；lungcancer；diagnosis Modem One