两种曲马多超前镇痛方法对乳腺癌术后的镇痛效果.pdfVIP

990 中国肿瘤临床 2012年第39卷第14期 两种曲马多超前镇痛方法对乳腺癌术后的镇痛效果 刘蔚然 邢玉红 李锦成 探讨两种曲马多超前镇痛方法对乳腺癌术后的镇痛效果和安全性。 将90例ASA评估Ⅰ～Ⅱ级拟行乳腺 摘要 目的： 方法： 癌根治术的女性患者随机分为3组，每组30例。A组：在手术切皮前10min和缝皮前10min给予曲马多1.5mg/kg；B组：切皮前 10min给予曲马多1.5mg/kg；C组：手术全程不给予曲马多。观察术后0.5、1、2、4、8、12、24h患者VAS疼痛评分和Ramsay镇静评 分以及相关并发症的发生。 A组术后12h以内VAS评分明显低于B组和C组，差异有统计学意义（P0.05），B组术后2h内 结果： VAS评分明显低于C组，差异有统计学意义（P0.05）。 曲马多超前镇痛对乳腺癌根治术后有明显的镇痛作用，并且在手术 结论： 开始和结束前联合给药效果更好。 关键词 曲马多 超前镇痛 乳腺癌 doi:10.3969/j.issn.1000-8179.2012.14.013 Effect of Two Tramadol Administration Methods on Postoperative Breast Cancer Pain Weiran LIU, Yuhong XING, Jincheng LI Correspondence to: Jincheng LI; E-mail: lijinchengmz@126.com Department of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China Abstract Objective: To investigate the preemptive analgesic efficacy of two tramadol administration methods on postoperative breast cancer pain. Methods: Ninety ASA Ⅰ～Ⅱfemale patients who underwent breast cancer surgery were randomly divided into 3 groups. Group A: Patients were administered 1.5 mg/kg tramadol 10 min before the operation and again 10 min before the end of operation, respectively. Group B: Patients were administered 1.5 mg/kg tramadol 10 min before the operation. Group C: Patients were not administered tramadol at any time. Data on pain, waking time, and side effects were recorded. Results: The Group A visual analog scale ( VAS ) values were lower than those of Groups B and C 12 h after the operation ( P 0.05 ). The Group B VAS values were lower than those of Group C 2 h after the operation ( P 0.05 ). Conclusion: Tramadol preemp