基于体素形态学揭示隐匿大血管病变影响2型糖尿病患者地脑微结构.docVIP

基于体素形态学揭示隐匿大血管病变影响2型糖尿病患者的脑微结构 2型糖尿病患者容易出现MRI影像上较明显的与认知功能障碍相关的脑萎缩，而在这些明显的萎缩出现之前，早期检出患者脑结构的细微变化，将助于及时干预并防止明显脑萎缩及相关认知功能障碍的出现。中国河北医科大学第二医院刘怀军所带领的团队，通过使用基于体素的形态学分析法，可以检测出2型糖尿病患者主要位于右颞叶和左枕叶脑早期细微的结构异常，并发现这些异常与早期隐匿的大血管病变及慢性高血糖状态密切相关。因此，作者认为，如果能够早期提供这些信息，使医生能够早期干预隐匿的大血管病变及控制血糖，可能阻止和延缓脑萎缩及与之相关的认知功能下降。相关文献发表于《中国神经再生研究（英文版）》杂志2014年8月第16期。 全脑范围基于体素的形态学分析显示，2型糖尿病患者右颞上回、左枕下回及右颞下回出现局部灰质丢失 Article: Brain structural changes and their correlation with vascular disease in type 2 diabetes mellitus patients: a voxel-based morphometric study, by Chunxia Wang1, Kailiang Fu1, Huaijun Liu1, Fei Xing1, Songyun Zhang2 (1 Department of Medical Imaging, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China; 2 Department of Endocrinology, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China) Wang CX, Fu KL, Liu HJ, Xing F, Zhang SY. Brain structural changes and their correlation with vascular disease in type 2 diabetes mellitus patients: a voxel-based morphometric study. Neural Regen Res. 2014;9(16):1548-1556. 欲获更多资讯Neural Regen Res Brain structure related with macroangiopathy in T2DM patients: a voxel-morphometric study Patients with type 2 diabetes mellitus (T2DM) may show brain atrophy with cognitive decline in MRI. However, early detection of microstructural changes in the brain can help to prevent against brain atrophy and cognitive dysfunction. A research team led by Huaijun Liu at the Second Hospital of Hebei Medical University in China using voxel-based morphometry detected differences in volumes of gray and white matter in the right temporal lobe in the absence of obvious decrease in total gray and white matter volume between T2DM patients and controls. These regional volume changes were correlated with macrovascular disease and chronic hyperglycemia. Researchers consider that to support these information as early as possible can alert the physician to macrovascular diseases that can be treated by early intervention and bl