神经生长因子及其受体在缺血缺氧性脑损伤中的作用机制.docVIP

目 录 一、中文摘要言结论 中 文 摘 要 目的：通过对 Abstracts Objective: Based on the rats with hypoxia ischemia brain damage model of injection unequal content of nerve growth factor and nerve in different parts of the model of normal rat growth factor concentration and receptor content comparison, draws the mechanism of nerve growth factor and its receptor in hypoxic ischemic brain damage in the clinical guidance for provide the basis for the treatment of ischemia and hypoxia injury cerebral. Methods: 1. Data from rats model: selection of animal center of Southern Medical University 16-18 weeks several big rats, male or female, the models were randomly selected, no statistical difference in results. 2. Methods: the rat model of the random sample of 50 in total, according to the different operation and operation whether injection of nerve growth factor conditions into 5 groups, normal fed rats in model group A, model group B the rat left carotid artery ligation operation, and in the continuous feeding daily injections of physiological saline; the rat model of C group to do the left carotid artery ligation operation, and in the daily injection of mouse nerve growth factor 30ug continuous feeding; rat model of D group to do the left carotid artery ligation operation, and in the daily injection of mouse nerve growth factor 60ug continuous feeding; rat model of E group to do the left carotid artery ligation operation, and in the daily injection of mouse nerve growth factor 90ug continuous feeding, the comparison of the five rats in the model group at 1 days after operation, one week after operation, two weeks after operation, postoperative around this several time periods, abdomen and tail head in different parts of nerve growth factor concentration and TrkB receptor content changes. 3. Data analysis: basic data in model rats with normal inspection, obey the normal distribution, and each group had no statistical difference. According to the 2*2 factorial design statistical analysis was p