高血压脑出血患者急性期血肿周围组织的炎症反应特征.docVIP

高血压脑出血患者急性期血肿周围组织的炎症反应特征 高血压脑出血患者急性期血肿周围组织的炎症反应特征 作者：董钊，石铸，王璐，陆兵勋，于生元 作者单位：100853 中国人民解放军总医院神经内科 (董钊, 于生元);南方医科大学南方医院神经内科 (石铸, 陆兵勋);南方医科大学病理学教研室 (王璐) 【摘要】 目的 探讨高血压脑出血患者血肿周围组织的炎症反应特征。方法 29例基底节区脑出血患者行微创血肿清除术,按出血后手术时间分为6～24 h组、24～48 h组及48 h组，将手术中引流的血肿周围脑组织行白细胞共同抗原(LCA)和细胞间黏附分子1(ICAM1) 免疫组化染色,并与对照组（非脑病尸检患者6例）进行比较。结果 脑出血组脑组织标本免疫组化染色可见LCA、ICAM1免疫阳性微血管及细胞，与对照组相比,表达量显著提高(均P0.01)；各时段组间LCA的表达差异无统计学意义；ICAM1的表达24～48 h组及48 h组显著高于6～24 h组(均P0.01)，24～48 h组与48 h组间差异无统计学意义。结论 脑出血急性期血肿周围脑组织存在急性炎症反应；ICAM1的表达在出血后48 h内逐渐增多。 【关键词】 脑出血；白细胞共同抗原；细胞间黏附分子1 　　Inflammatory reaction characteristics of perihematoma brain tissue in patients with acute hypertensive intracerebral hemorrhage DONG Zhao, SHI Zhu, WANG Lu, et al.Department of Neurology, General Hospital of PLA, Beijing 100853, China Abstract：Objective To investigate the inflammatory reaction characteristics of perihematomal brain tissue in patients with acute hypertensive intracerebral hemorrhage (ICH).Methods 29 patients who received minimally invasive surgery for ICH were divided into three groups according to the following bleeding time: 6～24 hours, 24～48 hours and 48 hours. The expressions of leukocyte common antigen (LCA) and intercellular adhesion molecule1 (ICAM1) in the brain tissues collected during the surgery were detected by immunohistochemistry staining method.Results LCA and ICAM1 immunopositive cells and microvessels were verified in all 29 cases of ICH groups, and the expressions were more than control group (all P0.01). There were no significant differences of LCA expression among different time group. The ICAM1 expressions in 24～48 hours group and 48 hours group were higher than that in 6～24 h group (both P0.01). There was no difference between 24～48 hours group and 48 hours group.Conclusions Acute inflammatory reaction occurs in acute period of ICH. Expression of ICAM1 reinforces gradually during early 48 hours since the onset of ICH. Key words：intracerebral