纳米石墨烯修饰电极三联吡啶钌电化学发光法测定盐酸雷尼替丁研究.pdfVIP

B038 纳米石墨烯修饰电极三联吡啶钌电化学发光法测定盐酸雷 尼替丁的研究 * 李焘，胡琪，吴佳雯，李晓宇，谭学才 ，雷福厚，黄在银 (广西民族大学化学化工学院；广西林产化学与工程重点实验室；广西高校化学与生物转化过程重点实 验室；南宁 530008) 摘要：基于盐酸雷尼替丁对联吡啶钌的电致化学发光信号的增敏作用，以石墨烯修饰的玻碳电极为工作 电极采用循环伏安法（CV ）和电化学发光(ECL)法研究了联吡啶钌（Ru(bpy)32+ ）和盐酸雷尼替丁（RTD ） 共存体系在该修饰电极上的电化学行为和电化学发光行为，建立了电化学发光法测定药物中盐酸雷尼替 丁的分析方法。结果表明，在0.1moL ／L 的磷酸盐(pH=8.5)缓冲溶液中，盐酸雷尼替丁在该修饰电极上 的检出限(S/N=3)为2.0×10-8 mol ／L ，在2.0×10-7~2×10-4moL ／L 范围内浓度与相对发光强度呈线性关系 (r=0.9978) 。 关键词：石墨烯；修饰电极；电致化学发光；盐酸雷尼替丁；三联吡啶钌 Determination of Ranitidine Based on Electrochemiluminescence from tris(2,2_-bipyridyl)ruthenium(II) and Graphene Modified Glassy Carbon Electrode * LI Tao, HU Qi , WU Jia-wen, LI Xiao-yu, TAN Xue-cai , LEI Fu-hou, HUANG Zai-yin (School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Key Laboratory of Chemical and Biological Transforming Process in Universities of Guangxi, Nanning 530008) 2+ Abstract ：Based on the enhancement of ECL characteristics of Ru(bpy)3 in the presence of ranitidine ，a new ECL method was established for the determination of chlorpromazine at the modified electrode which is modified by Graphene ．The behavior of electrochemical and electrochemiluminescence (ECL) was studied in that system by cyclic voltammetry (CV) on the glassy carbon electrode modified Graphene. Under optimal conditions，the concentration had a good linear relationship with the relative luminous intensity in the range of -7 -4 -8 2.0×10 ~2.0×10 moL ／L with