细胞膜表面核仁素的功能.pdfVIP

27 5 Vol. 27 N o. 5 2007 10 International Journal ofPathology and C linicalM edicine Oct. 2007 方 立 综述 王慷慨, 肖献忠 审校 (中南大学湘雅医学院病理生理教研室, 长沙 10078) [ ] 核仁素(又称 C23)是真核细胞核仁中最主要的一种蛋白质, 有多种生物学功能, 包括调控核糖体 的生物合成与成熟参与细胞增殖生长胚胎发生胞质分裂染色质复制核仁的发生以及抗细胞凋亡作用核 仁素可作为多功能穿梭蛋白穿梭于细胞浆和细胞核之间, 甚至表达在细胞膜上, 如肿瘤细胞免疫细胞以及血管内 皮细胞等, 这种细胞膜表面核仁素可充当多种蛋白分子细菌病毒的受体或共受体, 并介导这些配体的生物学效 应及病原微生物对宿主细胞的入侵 [ ] 核仁素/C23; 细胞膜; 表达; 功能 [ ] Q73 [ ] A [] 2007) 050 170 Function of nucleolin localized on the cell surface FANG Li, WANG KangK ai, X IAO X ianZhong (D ep artm ent of P ath op hy s iology, X iangya S ch ool of M ed icine, Centra l Sou th Un iv ers ity, Changsha 10078, C hina ) [ A bstract] Nucleolin is an abundant nucleolar phosphorylated proteinwh ich involves ribosome bi ogenesis andm aturation, cell growth and proliferation, cytokinesis, rep lication, embryogenesis, nucleo genesis and antiapoptosis. Recently, many stud ies show that nucleolin is a multifunctional shuttling pro tein present in nucleus, cytop lasm, and even on the surface of som e types of cells, such as tumor cells, mi mune cells and endothelial cells, etc. Themembraneanchored nucleolin is considered as a cell surface receptor for various ligands includ ingM idk in, P leiotroph in, Lactoferrin, H IV, Enterohemorrhagic Esche rich ia coli et a.l M any find ings suggest that cellsurface nucleolin med iates the ligandsrelated b iological response and invasion of pathogens to host cells. [ Key w ord s] nucleolin/C23; cellmembrane; expression; function