适量补充钙和维生素D是防治骨质疏_省略_补充钙和维生素D与骨折危险_一文_徐苓.pdf

2006 7 26 4 Intern J Endocr nol M etab, Jul 2006, Vol 26, No . 4 # 2 17 # ## D ) ) ) 评新英格兰医学杂志Jackson 等/ 补充钙和维生素D 与 骨折危险0 一文 徐苓 = 2006 2 16 ( NEJM ) / D 0 , D , D , , , : D , D = ; D; ; ; ; Adequate supplementation of calcium and vitamin D is the essential strategy for prevention and treatment of osteoporosis X ULing. Dep artment of Obstetrics and Gynecology, Peking UnionMedical College Hospital, Chinese cademy of Medical Science, Peking Union Medical College, Bejiing 100730, China = Abstract Comments w ere made on the paper t tled / Calc um Plus V tam n D Supplementat on and the R sk of Fracture0 publ shed recently n the New England Journal of Med c ne. It s a large random zed controlled tra l to evaluate the eff cacy of calc um w th v tam n D supplementat on for prevent ng h p and other fractures n healthy postmenopausal w omen . The results of th s tra l showed that among health postmenopausal women , calc um w th v tam n D supplementat on resulted n a small but s gn f cant mprovement on bone dens ty at h p , d d not s g- n f cantly reduce h p fracture, and ncreased the r sk of k dney stones . However, the results w ere obv ously affected by several l m tat ons of th s study, such as the des gn of the study, populat on selected and compl ance of the tra l . We concluded that due to these l m tat ons of th s tra l , no sol d ev dence w as off ered to deny the benef t of calc um plu s v tam n D supplementat on to bone health . Therefore, t s st ll recommended that adequate supple- mentat on of calc um and v tam n D s the essent al strategy for prevent on and treatment of osteoporos s. = Key words Calc um; V tam n D; Fracture; Osteoporos s; K dney stone; Ev dence-based med c ne (InternJ Endocrinol Metab, 2006, 26: 217-