miRNA-21及肿瘤相关研究新进展.pdfVIP

2011年第38 卷第6 期 中国肿瘤临床 357 miRNA-21与肿瘤相关研究新进展* 杨 旸 综述 康春生 审校 摘要 小RNA（microRNA ，miRNA ）是近年发现的一类内源性非编码单链RNA ，在转录后水平对基因表达发挥负调控作用， 参与细胞生长、发育、凋亡等重要生物过程。研究发现miRNA-21 在肿瘤的发生发展过程中扮演着非常重要的角色，在不同类型 肿瘤中的表达均出现明显上升，与肿瘤细胞的增殖、侵袭、血管的生成和抗药性等生物学行为相关。本文将从miRNA-21 的表达 与定位、对靶基因的调控以及对miRNA-21 的转录调控等方面进行综述。 关键词 miRNA-21 肿瘤 信号通路 转录 doi:10.3969/j.issn. 1000-8179.2011.06.016 Recent Advances in the Research on the Relationship between miRNA-21 and Cancer Yang YANG, Chunsheng KANG Correspondence to: Chunsheng KANG, E-mail: kang97061@ Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro-Onoclogy, Tianjin Neurological Insti- tute, Tianjin 300052, China This work was supported by National Natural Science Foandation of China (No and Science and Technology Planning Pro- gram of Tianjin (No.09JCZDJC 17600) Abstract MicroRNAs (mRNAs) are a class of endogenous small noncoding single-stranded RNAs that negatively regulate gene expression at the post-transcriptional level. MicroRNAs are involved in diverse biological processes, including development, cell differ- entiation and cell death. It was found that miRNA-21 played an important role in the course of oncogenesis. The expression of miR- NA-21 is significantly upregulated in different kinds of solid tumors. It is involved in cell proliferation, cell invasiveness, angiogenesis and other biological behaviors. This review summarizes the current knowledge concerning the expression and location of miRNA-21 and the regulatory network related to miRNA-21 in cancer. Keywords miRNA-21; Cancer; Signal transduction pathway; Transcription 小RNA （microRNA ，miRNA ）主要存在于真核生 文献报道了小RNA 是如何从编码区转录、如何经过 ［2-3 ］ 物基因组非编码区,在转录后水平调控一个或多个基 剪切加工而形成有功能的成熟体 。值