Diagnostic performance of regional DTIderived tensor.pdfVIP

Eur Radiol DOI 10.1007/s00330-012-2678-9 NEURO Albumin-binding MR blood pool contrast agent improves diagnostic performance in human brain tumour: comparison of two contrast agents for glioblastoma Josep Puig Gerard Blasco Marco Essig Josep Daunis-i-Estadella Gemma Laguillo Ana María Quiles Sebastián Remollo Karsten Bergmann Carme Joly Lluis Bernado Javier Sánchez-González Salvador Pedraza Received: 18 June 2012 / Revised: 30 August 2012 /Accepted: 22 September 2012 # European Society of Radiology 2012 Abstract to-noise ratio (SNR), contrast-to-noise ratio (CNR), and Objective We qualitatively and quantitatively compared contrast enhancement (CE). MRI enhancement obtained with gadofosveset, an Results Mean values of SNR, CNR, and tumour CE were albumin-binding blood-pool contrast agent, and with highest 6 h after gadofosveset. Multifocality was seen in 17 gadobutrol, an extracellular contrast agent, in patients with (48.6 %) patients; additional lesions had stronger enhance- glioblastoma. ment 6 h after gadofosveset in 12 patients (70.6 %). In 21 Methods Thirty-five patients (25 men; 64±14 years) with (60 %) patients, radiologists’ global preference was highest histologically proven glioblastoma underwent MRI includ- in images acquired 6 h after gadofosveset (kappa0 0.764). In ing pre- and post-contrast T1-weighted SE images acquired 22 patients (62.8 %), all qualitative endpoints were better at 5 min after gadobutrol (0.1 mmol/kg) and, 48 h later, images 5 min after gadobutrol than in images acquired 5 min after acquired with identical parameters 5 min and 3, 6, and 24 h gadofosveset injection. after gadofosveset