COPD病人肺组织中NFB的表达及意义.pdf

47 5 V ol. 47, N o. 5 20 11 10 A CT A A CA DEM IA E M ED ICIN AE Q IN G DA O U N IV ERS IT A T IS O ct ober 20 11 COPD 病人肺组织中N F- B 的表达及意义 1 2 1 , , ( 1 , 266003; 2 ICU) [ -B( N F-B) ( CO PD) COPD COP D 15 , , N F-B , DN A CO PD N F-B CO PD ( t = 4. 074 ~ 6. 474, P 0 . 0 1) CO PD ( t= 25. 8324. 02, P 0 . 0 1) ; ( t= 3. 27, P 0 . 01) ; N F-B ( r= 0. 8230. 774, P 0 . 0 1) , ( r= - 0. 652, P 0. 01) NF-B , [ , ; N F-B; [ R563 [ A [ 1672- 4488( 2011) 05- 0429-0 3 EXPRESSION OF NUCLEAR FACTOR- B IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE ZH A N G J IE, LEN G CH UA N-LI , YU WEN-CH EN G ( D epart ment of Pulm on ary Diseases , T h e A f f iliated H ospit al of Q ingdao U niver- s ity M edical C ol lege , Q in gdao 266003, Chin a) [ ABSTRACT] Obj ect ive T o invest igat e t he r ol e of nucl ear fact or- B expr ess ion and it s s ignif ican ce in patient s w it h chronic ob st ruct ive pul monary disease ( COPD) . Met hod s Lun g specimen s f rom pat ient s w it hout COP D ( non- COP D group) , and pa- t ient s w it h COP D ( COPD group) , 15 in each group, w er e in vest igat ed. T he ex pres sion of N F- B w as det ect ed imm unohist ochemi- call y , and t ermi nal deoxynu cleotidyl t ran sf erase-mediat ed d- UT P nick end lab elin g ( T U N EL ) t echnique w as u sed t o det ect t he apopt osis. Result s In COP D group, t h e N F-B expression of bronchial epit helial cell s ( BEC s) , al veolar epit helial cell s ( A ECs ) , and bronchial sm oot h mu scle cel ls ( BSM Cs ) was h igher t h an t hat in