Sequence analysis The Global Trace Graph, a Novel Paradigm for Searching Protein Sequence D.pdfVIP
- 1、本文档共7页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Sequence analysis The Global Trace Graph, a Novel Paradigm for Searching Protein Sequence D
Bioinformatics Advance Access published September 6, 2007
Sequence analysis
The Global Trace Graph, a Novel Paradigm for Searching Protein
Sequence Databases
Andreas Heger1,3, Swapan Mallick1,4, Christopher Wilton1,5 and Liisa Holm,*1,2
1Institute of Biotechnology and 2Department of Biological and Environmental Sciences, Division of Genetics, P.O.Box 56 (Viikinkaari 5), FI-00014 Univer-
sity of Helsinki, Finland. 3 Current address: MRC Functional Genetics Unit, Department of Physiology, Anatomy Genetics, University of Oxford, South
Parks Road, OX1 3QX Oxford, U.K. 4 Current address: Department of Gernetics, Harvard Medical School, Boston, MA. 5 Current address: Babraham Insti-
tute, Cambridge, U.K.
Associate Editor: Prof. Burkhard Rost
ABSTRACT proteins (Heger et al. 2005, Kaplan et al. 2005, Heger Holm
Motivation: Propagating functional annotations to sequence-similar, 2000 and references therein) have the advantage of completeness,
presumably homologous proteins lies at the heart of the bioinformat- but the determination of the boundary between homologous and
ics industry. Correct propagation is crucially dependent on the accu- unrelated sequences is unreliable or simply left to the user. To
maximize information transfer, there is a need for methods which
rate identification of subtle sequence motifs that are conserved in
are able to traverse large evolutionary distances while discriminat-
evolution. The evolutionary signal can be difficult to detect because
ing against unrelated sequences. For example, a series
您可能关注的文档
- PQRASME要求填写的焊接工艺评定报告.doc
- Practical Automatic Determination of Causal Relationships in Software Execution Traces.pdf
- Prediction of Physical, Color, and Sensory Characteristics of Broiler Breasts by VisibleNea.pdf
- Precision Spectroscopy of Pionic Atoms From Pion Mass Evaluation to Tests of Chiral Perturb.pdf
- Predictive Evaluation of Econometric Forecasting Models in Commodity Futures Markets.pdf
- Predicting the Performance of Randomized Parallel Search An Application to Robot Motion Pla.pdf
- PRELIMINARY VERSION A Design Diversity Metric and Analysis of Redundant Systems.pdf
- Present and NearFuture Reflected Light Searches for CloseIn Planets.pdf
- prepared for a special issue of abour Economics,.pdf
- Present and Future Electroweak Precision Measurements and the Indirect Determination of the.pdf
文档评论(0)