Cancer risk analysis and assessment of trihalomethanes in drinking water英文资料.pdfVIP

Stoch Environ Res Risk Assess (2006) 21: 1–13 DOI 10.1007/s00477-006-0039-4 ORIGINAL PAPER Han-Keng Lee Æ Yir-Yarn Yeh Æ Wei-Ming Chen Cancer risk analysis and assessment of trihalomethanes in drinking water Published online: 22 February 2006 Springer-Verlag 2006 Abstract This study conducts risk assessment for an ar- Bellar et al. (1974) exhibited that disinfection by-prod- ray of health effects that may result from exposure to ucts (DBPs) were produced in the disinfection process. disinfection by-products (DBPs). An analysis of the Nowadays, such disinfection process is most adopted in relationship between exposure and health-related out- drinking water treatment commonly (Houston 1913; comes is conducted. The trihalomethanes (THMs) spe- Yang et al. 1998; Hsu et al. 2001). cies have been verified as the principal DBPs in the Disinfection by-products are defined as hazardous drinking water disinfection process. The data used in materials with carcinogenic risk by Taiwan USEPA. this study was collected from the Taiwan Water Cor- Animal and epidemiology study evaluations have shown poration (TWC) from 1998 to 2002. Statistical analysis, that developmental toxicity and adverse effects are the multistage of Benchmark model, Monte Carlo simula- main potential risks to humans. The result from animal tion (MCS) and sensitive analysis were used to estimate studies demonstrated evidence of liver, kidney, intestinal the cancer risk analysis and assessment. This study in- tumor genesis, urinary bladder, rectum and colon cancer cluded the statistical data analysis, epidemiology inves- (Morris et al. 1992; Doyle et al. 1997; Cantor et al. 1998) tigation and cancer risk assessment of THMs species in and some associated effects of intra