抗环瓜氨酸肽抗体与类风湿性关节炎骨侵蚀相关性研究_杨静.pdfVIP

658 WEST CHINA MEDICAL JOURNAL 2005, Vo1.20, No.4　CN 51-1356/R [] 1002-0179 (2005)04-0658-03 Study onthe CorrelationbetweenAnti-cyclic CitrullinatedPeptideAntibodyandErosion of BoneinPatientswithRheumatoid Arthritis 杨静, 刘云, 奉家富, 吴茜, 向礼贤, 肖成明, 王宏志, 胡容, 苏牟潇 YA NG Jing, LIU Yun, FENG Jia-fu, et al. (, 　621000) (Miany ang Central Hosp ital .Miany ang 621000, China) 　　:: (CCP ) (IgM-RF) (RA) 。: 106 , 273 (RA 132 , 91, 50 )。379 CCP IgM-RF , 106 RA X , Sharp , CCP 、 IgM-RF 、 、 。:CCP RA (P0.01), IgM-RF (P0.05)。CCP IgM -RF RA 、 、 : CCP (66.04%, 98.90%, 60.09, 0.34), IgM-RF (74.53%, 79.49%, 3.63, 0.32)。 CCP IgM -RF 58.49%、 99.27%, 83.56、 0.42。CCP 、 IgM-RF, IgM-RF CCP , 、 , 。:CCP , IgM-RF 。CCP RA , IgM-RF , 、 、 , 。CCP RA 。 :;;;; [] R593.22　　　 [] A Abstract:Objecti e:To e aluate the diagnostic alues of anti-cy clic citrullinated peptide antibody (anti-CCP)and IgM rheumatoid factors (IgM-RF)in Rheumatoid Arthritis (RA), and to examine the the correlation between them and the se erity of erosion of bone in rheumatoid arthritis.Methods:serum anti-CCP antibodies were detected in 379 cases.106 cases from pa- tients with established RA and 273 from non-RA controls, including 223 patients with non-RA diseases and 50 healthy sub- jects.IgM-RFwere also assayed in all sample, and the results were compared to anti-CCP for sensiti ity, specificity, positi e likelihood ratio (+LR)and negati e likelihood ratio (-LR).Radiographs of hands and feet were simultaneo-usly conducted, sharp scores also e aluated.Patients were di ided into the erosi e of bone group and the non-erosi e group based on sharp scores.The correlation betw