《Effects of La3 on osteogenic and adipogenic differentiation of primary mouse bone marrow stromal cells》.pdfVIP
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onlineatwww.sciencedirect.com
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·:j二,ScienceDireCt
RARE
JOURNALOF EARTHS,VoLJO,No.1.Jan.2012.P.90
EffectsofLa3+on and differentiationof
osteogenicadipogenic primary
marrowstromal
mousebone cells
.
zH Dandan
0hi月丹)1,
ANG胁11ao(张金翱1,SUNJing(孙静)2,GUGuangqi(谷广期1,HAOXiaoh0Ilg(郝晓红)1,LIU
LI
Yaping(李业平)1,QINXinying(秦新英)1,WANGShuxiang(王书香)1
tad
ofHebeiUniversity,Baoding071000,China)
Received31
March201l;revised22April2011
Abstract:InordertoelucidatetheactionofLaj+onbone ofLa”onthe and differentiationof口ri—
metabolism,effectsosteogenicadipogenic
mousebonemarrowstromal studied tetrazolium
mary cells(BMSCs)wgreby3-(4,5-dimethylthiazol一2-y1)-2,5-diphenyl
alkaline red0stainandmeasurement.Theresultsshowedthat
phosphatase(ALP)activitymeasulglllent,mineralizedfunction,oil L矿’pro-
lxloooandl×l旷mol/L.111e con-
motedtheproliferationofBMSCsexceptat
formationof
eentrationsatthe7th the differentiationwasinhibitedat concentrationatthe14th the
day.butosteogenic any day.La’+promoted
mineralizedmatrixnodulesatl×l旷andl×l旷mol/L.La3+inhibiteddifferentiationatl×10。”andl×lo-7mol/L
except adipogenic except
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