《Effects of Low Concentrations of Di2ethylhexyl and Mono2ethylhexyl Phthalate on Steroidogenesis Pathways and Apoptosis in the Murine Leydig Tumor Cell Line MLTC1》.pdfVIP

986 Biomed Environ Sci, 2013; 26(12): 986-989 Letter to the Editor Effects of Low Concentrations of Di-(2-ethylhexyl) and Mono-(2-ethylhexyl) Phthalate on Steroidogenesis Pathways and Apoptosis in the Murine Leydig Tumor Cell Line MLTC-1* 1 1 1 1 2 1,# CHEN Xi , LIU Ya Nan , ZHOU Qing Hong , LENG Ling , CHANG Ying , and TANG Nai Jun The aim of this study was to evaluate the from the inhibition of enzymes expression effects of low concentrations of DEHP and MEHP on involved in cholesterol uptake/transport and steroidogenesis in a murine Leydig tumor cell line steroidogenesis. However, few documents have (MLTC-1) in vitro. The result of flow cytometry been published about the effects of low level of analysis revealed that the proportion of apoptotic DEHP or MEHP. Indeed, much attention should be cells was significantly increased after the exposure paid to the effects of low-dose endocrine disrupting to DEHP. All three genes (P450scc, P450c17, and chemicals (EDCs), since it is a common phenomenon 3βHSD) under study showed an increased for humans to be exposed to low-doses of expression following exposure to DEHP or MEHP, phthalates[2]. although some insignificant inhibitory effects Phthalates may exert antiandrogenic effects by appeared in the 10 μmol/L treatment group as impairing testosterone synthesis in the testis,