《Effects of low level laser treatment on the survival of axotomized retinal ganglion cells in adult Hamsters》.pdfVIP

NEURAL REGENERATION RESEARCH November 2014,Volume 9,Issue 21 Effects of low level laser treatment on the survival of axotomized retinal ganglion cells in adult Hamsters Kwok-Fai So1, 2, 3, Mason Chin Pang Leung2, 4, Qi Cui1 1 GHM Institute of CNS Regeneration, and Guangdong Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, Guangdong Province, China 2 Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China 3 Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China 4 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special Administrative Region, China Abstract Kwok-Fai So and Mason Chin Pang Leung Injury to axons close to the neuronal bodies in the mammalian central nervous system causes contributed equally to this work. a large proportion of parenting neurons to degenerate. It is known that optic nerve transection close to the eye in rodents leads to a loss of about half of retinal ganglion cells in 1 week and Corresponding author: about 90% in 2 weeks. Using low level laser treatment in the present study, we demonstrated that Kwok-Fai So, GHM Institute of CNS treatment with helium-neon (660 nm) laser with 15 mW power could delay retinal ganglion cell Regeneration, Jinan University, death after optic nerve axotomy in adult hamsters. The effect was most apparent in the first week Guangzhou, Guangdong Province, China, with a short period of treatment time (5 minutes) in which 65–66% of retinal ganglion cells hrmaskf@hku.hk. survived the optic nerve