《Efficacy and Immune Mechanisms of Cetuximab for the Treatment of Metastatic Colorectal Cancer》.pdfVIP
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Oncol
Clin Cancer 207
Res(2011)8:207—214
10.1
DOl 0071siI805.011.0582—8
andImmuneMechanismsofCetuximabforthe
Efficacy
TreatmentofMetastaticColorectaICancer
ABSTRACTCetuximabisachimeric G1mono.
HaozHUANGl immunoglobuIin
clonaI that the domainofthe
XUP antibodytargetsIigand—binding
Zhen-vi
factor andjnhibitsdownstreamintra—
epidermaIgrowth receptor
£ul,I正AJ\『G7 cellular hasshownthatcetuximabcan
signals.Research
L17 theautoimmuneand ceIIUIar
Xiao-yan systemproduce
and reactions,
zHANGl cytotoxicitycomplement—dependentcytotoxicity
Ninq
whichcanrecruit toattackandkiIIcancer
cytotoxic
zHANGl,2 Iymphocytes
Rong-xin
cells.Cetuximabis indicatedfor with
mainly patients
factor metastaticcolorectalcancerwho
growth receptor—positive
failto toboth
irinotecan—and
respond oxaliplatin.basedregimens.
The and ofcetuximabas orin
efficacysafety monotherapy
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