《Implanting iodine125 seeds into rat dorsal root ganglion for neuropathic pain：neuronal microdamage without impacting hind limb motion》.pdfVIP

NEURAL REGENERATION RESEARCH June 2014,Volume 9,Issue 12 Implanting iodine-125 seeds into rat dorsal root ganglion for neuropathic pain: neuronal microdamage without impacting hind limb motion 1 1 2 1 1 2 2 2 Ling Jiao , Tengda Zhang , Huixing Wang , Wenyi Zhang , Saijun Fan , Xiaodong Huo , Baosen Zheng , Wenting Ma 1 Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin, China 2 Second Affiliated Hospital of Tianjin Medical University, Tianjin, China Abstract Ling Jiao and Tengda Zhang contributed The use of iodine-125 (125I) in cancer treatment has been shown to relieve patients’ pain. Consid- equally to this work. ering dorsal root ganglia are critical for neural transmission between the peripheral and central nervous systems, we assumed that 125I could be implanted into rat dorsal root ganglia to provide Corresponding author: relief for neuropathic pain. 125I seeds with different radioactivity (0, 14.8, 29.6 MBq) were im- Wenting Ma, Second Affiliated Hospital planted separately through L and L intervertebral foramen into the vicinity of the L dorsal 4–5 5–6 5 of Tianjin Medical University, Tianjin root ganglion. von Frey hair results demonstrated the mechanical pain threshold was elevated 300211, China, after implanting 125I seeds from the high radioactivity group. Transmission electron microscopy md518880@163.com. revealed that nuclear membrane shrinkage, nucl