《Growth factorand cytokinestimulated endothelial progenitor cells in postischemic cerebral neovascularization》.pdfVIP

NEURAL REGENERATION RESEARCH August 2014,Volume 9,Issue 15 INVITED REVIEW Growth factor- and cytokine-stimulated endothelial progenitor cells in post-ischemic cerebral neovascularization Philip V. Peplow Department of Anatomy, University of Otago, Dunedin, New Zealand Abstract Corresponding author: Endothelial progenitor cells are resident in the bone marrow blood sinusoids and circulate in the Philip V. Peplow, Department of peripheral circulation. They mobilize from the bone marrow after vascular injury and home to Anatomy, University of Otago, 270 Great the site of injury where they differentiate into endothelial cells. Activation and mobilization of King Street, Dunedin, New Zealand, endothelial progenitor cells from the bone marrow is induced via the production and release of phil.peplow@stonebow.otago.ac.nz. endothelial progenitor cell-activating factors and includes specific growth factors and cytokines in response to peripheral tissue hypoxia such as after acute ischemic stroke or trauma. Endotheli- doi:10.4103/1673-5374.139457 al progenitor cells migrate and home to specific sites following ischemic stroke via growth factor/ cytokine gradients. Some growth factors are less stable under acidic conditions of tissue isch- / emia, and synthetic analogues that are stable at low pH may provide a more effective therapeutic approach for inducing endothelial progenitor cell mobilization and promoting cerebral neovas- Accepted: 2014-06-20 cularization following ischemic stroke. Key Words: endothelial progenitor ce