2009_4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila外文翻译.PDFVIP

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila Brian M. Zid,1,4,* Aric N. Rogers,2,3 Subhash D. Katewa,2,3 Misha A. Vargas,2 Marysia C. Kolipinski,2 Tony Au Lu,1 Seymour Benzer,1 and Pankaj Kapahi2,* 1California Institute of Technology, Pasadena, CA 91125, USA 2Buck Institute for Age Research, Novato, CA 94945, USA 3These authors contributed equally to this manuscript 4Present address: Harvard University, Cambridge, MA 02138, USA *Correspondence: pkapahi@ (P.K.), zid@ (B.M.Z.) DOI 10.1016/j.cell.2009.07.034 SUMMARY slows aging and age-related diseases. It has become apparent in recent years that nutrient sensing growth pathways are im- Dietary restriction (DR) extends lifespan in multiple portant regulators of lifespan. The target of rapamycin (TOR) species. To examine the mechanisms of lifespan pathway, a key nutrient sensing pathway conserved from yeast extension upon DR, we assayed genome-wide transla- to humans, integrates nutrient and environmental signals to tional changes in Drosophila. A number of nuclear en- mediate growth and metabolism. coded mitochondrial genes, including those in Mutants in the nutrient sensing TOR pathway display pleio- Complex I and IV of the electron transport chain, tropic phenotypes. In Drosophila melanogaster , larvae lacking TOR show similarities to amino acid-deprived animals, such as showed increased ribosomal loading and enhanced reduced nucleolar size, developmental arrest and lipid