《LCMSMS Method for the Quantitation of Cefotetan in Human Plasma and Its Application to Pharmacokinetic Study》.pdfVIP
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1
Chem.Res.Chin.Univ.,20
4,30(6),900一904
LC—MS/MSMethodforthe ofCefotetaninHuman
Quantitation
Pharmacokinetic
PlasmaandIts to
Application Study
SHI
Meiyunl,_,YINLeil,_,CAILanlanl,WANGCanl,LIUXidon91,ZHAOSenl,SUNYanton93,
FAWCETTJ.Paul4.ZHAOLimei5.YANGYanl’andGU
Jingkail,2’
R
Science.Jilin 130012.PChina;
1.CollegeofLife University,Changchun
2.Clinical Institute First
Center,ResearchofTranslationalMedicine,the University
Pharmacology HospitalofJilin
130061.P
Changchun R.China;
3.School
ofPharmaceuticalSciences,JilinUniversity,Changchun130021,PR.China;
4.School 9054,NewZealand;
ofOtago,Dunedin
ofPharmacy,University
5.TheSecondClinical toChineseMedical 110004.PR.China
HospitatAffiliated University,Shenyang
A andsensitive mass forthede··
Abstract
rapid liquidchromatography-tandemspectrometry(LC-MS/MS)method
terminationofcefotetaninhuman was andvalidated.Afterthe of with
plasmadeveloped proteinprecipitationsample
andinternal onaZorbaxXDBcolumnace-
acetonitrile,th
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